The reduction of postlaminectomy peridural fibrosis in rabbits by a carbohydrate polymer

J. T. Robertson, A. L. Meric, F Dohan, J. B. Schweitzer, J. R. Wujek, S. Ahmad

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Spinal peridural fibrosis following total laminectomy in New Zealand White rabbits was significantly decreased by the intraoperative application of GT1587, a semi-synthetic carbohydrate polymer. The application of a similar polymer, GT1043, or phosphate-buffered saline (PBS) was not as effective. Laminectomies were performed at L-2 and L-4 in 25 rabbits. Absorbable gelatin sponge soaked with GT1043, GT1587, or PBS was applied in a blinded fashion to the operative sites, with untreated (sham) laminectomy sites serving as controls. Animals were sacrificed after 2 or 4 weeks. The extent of peridural fibrosis was evaluated by gross microdissection and histological analysis. Dense scar formation and dural adhesions were evident at both time intervals in the sham- and PBS-treated laminectomy sites. The sites treated with GT1587 showed significantly decreased peridural scar formation and dural adhesions, whereas GT1043 treatment caused modest reduction of scar formation at only the 2-week examination. The healing of skin and lumbosacral fascia was not affected by treatment of the laminectomy site with GT1587. These results suggest that GT1587 may prove beneficial in preventing postlaminectomy dural adhesions and peridural fibrosis in humans.

Original languageEnglish (US)
Pages (from-to)89-95
Number of pages7
JournalJournal of neurosurgery
Volume79
Issue number1
DOIs
StatePublished - Jan 1 1993

Fingerprint

Laminectomy
Polymers
Fibrosis
Carbohydrates
Rabbits
Cicatrix
Phosphates
Absorbable Gelatin Sponge
Microdissection
Fascia
GT 1587
Skin
GT 1043

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

The reduction of postlaminectomy peridural fibrosis in rabbits by a carbohydrate polymer. / Robertson, J. T.; Meric, A. L.; Dohan, F; Schweitzer, J. B.; Wujek, J. R.; Ahmad, S.

In: Journal of neurosurgery, Vol. 79, No. 1, 01.01.1993, p. 89-95.

Research output: Contribution to journalArticle

Robertson, J. T. ; Meric, A. L. ; Dohan, F ; Schweitzer, J. B. ; Wujek, J. R. ; Ahmad, S. / The reduction of postlaminectomy peridural fibrosis in rabbits by a carbohydrate polymer. In: Journal of neurosurgery. 1993 ; Vol. 79, No. 1. pp. 89-95.
@article{9082bf6bca9e420fb1e9eea614fd1354,
title = "The reduction of postlaminectomy peridural fibrosis in rabbits by a carbohydrate polymer",
abstract = "Spinal peridural fibrosis following total laminectomy in New Zealand White rabbits was significantly decreased by the intraoperative application of GT1587, a semi-synthetic carbohydrate polymer. The application of a similar polymer, GT1043, or phosphate-buffered saline (PBS) was not as effective. Laminectomies were performed at L-2 and L-4 in 25 rabbits. Absorbable gelatin sponge soaked with GT1043, GT1587, or PBS was applied in a blinded fashion to the operative sites, with untreated (sham) laminectomy sites serving as controls. Animals were sacrificed after 2 or 4 weeks. The extent of peridural fibrosis was evaluated by gross microdissection and histological analysis. Dense scar formation and dural adhesions were evident at both time intervals in the sham- and PBS-treated laminectomy sites. The sites treated with GT1587 showed significantly decreased peridural scar formation and dural adhesions, whereas GT1043 treatment caused modest reduction of scar formation at only the 2-week examination. The healing of skin and lumbosacral fascia was not affected by treatment of the laminectomy site with GT1587. These results suggest that GT1587 may prove beneficial in preventing postlaminectomy dural adhesions and peridural fibrosis in humans.",
author = "Robertson, {J. T.} and Meric, {A. L.} and F Dohan and Schweitzer, {J. B.} and Wujek, {J. R.} and S. Ahmad",
year = "1993",
month = "1",
day = "1",
doi = "10.3171/jns.1993.79.1.0089",
language = "English (US)",
volume = "79",
pages = "89--95",
journal = "Journal of Neurosurgery",
issn = "0022-3085",
publisher = "American Association of Neurological Surgeons",
number = "1",

}

TY - JOUR

T1 - The reduction of postlaminectomy peridural fibrosis in rabbits by a carbohydrate polymer

AU - Robertson, J. T.

AU - Meric, A. L.

AU - Dohan, F

AU - Schweitzer, J. B.

AU - Wujek, J. R.

AU - Ahmad, S.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Spinal peridural fibrosis following total laminectomy in New Zealand White rabbits was significantly decreased by the intraoperative application of GT1587, a semi-synthetic carbohydrate polymer. The application of a similar polymer, GT1043, or phosphate-buffered saline (PBS) was not as effective. Laminectomies were performed at L-2 and L-4 in 25 rabbits. Absorbable gelatin sponge soaked with GT1043, GT1587, or PBS was applied in a blinded fashion to the operative sites, with untreated (sham) laminectomy sites serving as controls. Animals were sacrificed after 2 or 4 weeks. The extent of peridural fibrosis was evaluated by gross microdissection and histological analysis. Dense scar formation and dural adhesions were evident at both time intervals in the sham- and PBS-treated laminectomy sites. The sites treated with GT1587 showed significantly decreased peridural scar formation and dural adhesions, whereas GT1043 treatment caused modest reduction of scar formation at only the 2-week examination. The healing of skin and lumbosacral fascia was not affected by treatment of the laminectomy site with GT1587. These results suggest that GT1587 may prove beneficial in preventing postlaminectomy dural adhesions and peridural fibrosis in humans.

AB - Spinal peridural fibrosis following total laminectomy in New Zealand White rabbits was significantly decreased by the intraoperative application of GT1587, a semi-synthetic carbohydrate polymer. The application of a similar polymer, GT1043, or phosphate-buffered saline (PBS) was not as effective. Laminectomies were performed at L-2 and L-4 in 25 rabbits. Absorbable gelatin sponge soaked with GT1043, GT1587, or PBS was applied in a blinded fashion to the operative sites, with untreated (sham) laminectomy sites serving as controls. Animals were sacrificed after 2 or 4 weeks. The extent of peridural fibrosis was evaluated by gross microdissection and histological analysis. Dense scar formation and dural adhesions were evident at both time intervals in the sham- and PBS-treated laminectomy sites. The sites treated with GT1587 showed significantly decreased peridural scar formation and dural adhesions, whereas GT1043 treatment caused modest reduction of scar formation at only the 2-week examination. The healing of skin and lumbosacral fascia was not affected by treatment of the laminectomy site with GT1587. These results suggest that GT1587 may prove beneficial in preventing postlaminectomy dural adhesions and peridural fibrosis in humans.

UR - http://www.scopus.com/inward/record.url?scp=0027161739&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027161739&partnerID=8YFLogxK

U2 - 10.3171/jns.1993.79.1.0089

DO - 10.3171/jns.1993.79.1.0089

M3 - Article

VL - 79

SP - 89

EP - 95

JO - Journal of Neurosurgery

JF - Journal of Neurosurgery

SN - 0022-3085

IS - 1

ER -