The reemergence of serious group A streptococcal infections and acute rheumatic fever

Michael S. Bronze, James Dale

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Acute rheumatic fever and life-threatening group A streptococcal infections have reemerged during the past 15 years to once again become a serious health threat in the developed countries of the world. Reports of outbreaks of acute rheumatic fever in many parts of this country and others have shattered the complacency that the health-care community had acquired related to this devastating sequela of streptococcal pharyngitis. Invasive streptococcal infections, often associated with loss of limbs or life despite optimal antibiotic therapy, have underscored the potential virulence of these organisms. A new clinical entity, streptococcal toxic shock syndrome, has emerged as a consequence of the new invasive strains of group A streptococci. In this article, the authors summarize the recent changes in the epidemiology of group A streptococcal infections and rheumatic fever and review the potential reasons for the increased virulence of these organisms. In addition, they discuss prospects for a streptococcal M protein vaccine designed to control these infections and their sequelae.

Original languageEnglish (US)
Pages (from-to)41-54
Number of pages14
JournalAmerican Journal of the Medical Sciences
Volume311
Issue number1
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

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Streptococcal Infections
Rheumatic Fever
Virulence
Pharyngitis
Infection Control
Septic Shock
Streptococcus
Developed Countries
Disease Outbreaks
Epidemiology
Vaccines
Extremities
Anti-Bacterial Agents
Delivery of Health Care
Health
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

The reemergence of serious group A streptococcal infections and acute rheumatic fever. / Bronze, Michael S.; Dale, James.

In: American Journal of the Medical Sciences, Vol. 311, No. 1, 01.01.1996, p. 41-54.

Research output: Contribution to journalArticle

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