The renin-angiotensin-aldosterone system and vascular remodeling

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Cardiac fibrosis can be accompanied initially by diastolic and ultimately by systolic ventricular dysfunction. Clinical and experimental evidence suggests a clear association between such adverse structural remodeling and activation of the circulating renin-angiotensin-aldosterone system (RAAS). Infusion of either of two RAAS effector hormones, angiotensin II and aldosterone, in rats evokes perivascular fibrosis of arteries and arterioles of the heart and kidneys. Additionally, increasing evidence indicates locally produced angiotensin II and aldosterone have important paracrine and autocrine actions that play a role in vascular remodeling. Both angiotensin II and aldosterone receptor antagonists have been shown to attenuate the appearance of cardiac and renal fibrosis.

Original languageEnglish (US)
Pages (from-to)11-16
Number of pages6
JournalCongestive Heart Failure
Volume8
Issue number1
StatePublished - May 11 2002

Fingerprint

Renin-Angiotensin System
Fibrosis
Aldosterone
Angiotensin II
Mineralocorticoid Receptor Antagonists
Ventricular Dysfunction
Kidney
Angiotensin Receptor Antagonists
Arterioles
Arteries
Hormones
Vascular Remodeling

All Science Journal Classification (ASJC) codes

  • Emergency Medicine
  • Emergency
  • Cardiology and Cardiovascular Medicine

Cite this

The renin-angiotensin-aldosterone system and vascular remodeling. / Sun, Yao.

In: Congestive Heart Failure, Vol. 8, No. 1, 11.05.2002, p. 11-16.

Research output: Contribution to journalReview article

@article{e23fbd81f05847f2bda210be9e317f5d,
title = "The renin-angiotensin-aldosterone system and vascular remodeling",
abstract = "Cardiac fibrosis can be accompanied initially by diastolic and ultimately by systolic ventricular dysfunction. Clinical and experimental evidence suggests a clear association between such adverse structural remodeling and activation of the circulating renin-angiotensin-aldosterone system (RAAS). Infusion of either of two RAAS effector hormones, angiotensin II and aldosterone, in rats evokes perivascular fibrosis of arteries and arterioles of the heart and kidneys. Additionally, increasing evidence indicates locally produced angiotensin II and aldosterone have important paracrine and autocrine actions that play a role in vascular remodeling. Both angiotensin II and aldosterone receptor antagonists have been shown to attenuate the appearance of cardiac and renal fibrosis.",
author = "Yao Sun",
year = "2002",
month = "5",
day = "11",
language = "English (US)",
volume = "8",
pages = "11--16",
journal = "Prevention and Management of Congestive Heart Failure",
issn = "1079-7998",
publisher = "Le Jacq Communications, Inc.",
number = "1",

}

TY - JOUR

T1 - The renin-angiotensin-aldosterone system and vascular remodeling

AU - Sun, Yao

PY - 2002/5/11

Y1 - 2002/5/11

N2 - Cardiac fibrosis can be accompanied initially by diastolic and ultimately by systolic ventricular dysfunction. Clinical and experimental evidence suggests a clear association between such adverse structural remodeling and activation of the circulating renin-angiotensin-aldosterone system (RAAS). Infusion of either of two RAAS effector hormones, angiotensin II and aldosterone, in rats evokes perivascular fibrosis of arteries and arterioles of the heart and kidneys. Additionally, increasing evidence indicates locally produced angiotensin II and aldosterone have important paracrine and autocrine actions that play a role in vascular remodeling. Both angiotensin II and aldosterone receptor antagonists have been shown to attenuate the appearance of cardiac and renal fibrosis.

AB - Cardiac fibrosis can be accompanied initially by diastolic and ultimately by systolic ventricular dysfunction. Clinical and experimental evidence suggests a clear association between such adverse structural remodeling and activation of the circulating renin-angiotensin-aldosterone system (RAAS). Infusion of either of two RAAS effector hormones, angiotensin II and aldosterone, in rats evokes perivascular fibrosis of arteries and arterioles of the heart and kidneys. Additionally, increasing evidence indicates locally produced angiotensin II and aldosterone have important paracrine and autocrine actions that play a role in vascular remodeling. Both angiotensin II and aldosterone receptor antagonists have been shown to attenuate the appearance of cardiac and renal fibrosis.

UR - http://www.scopus.com/inward/record.url?scp=0036238726&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036238726&partnerID=8YFLogxK

M3 - Review article

VL - 8

SP - 11

EP - 16

JO - Prevention and Management of Congestive Heart Failure

JF - Prevention and Management of Congestive Heart Failure

SN - 1079-7998

IS - 1

ER -