The role of activators in assembly of RNA polymerase II transcription complexes

Roderick Hori, Michael Carey

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

The past year has provided new insights into the biochemical mechanism of gene activation. Key discoveries include the finding that TFIIA plays an important regulatory role in transcription complex assembly, the TBP-associated factors are direct targets of at least two classes of activator, and a largely pre-assembled transcription complex has been isolated from yeast cells, challenging the step-wise assembly pathway. This review also presents an update on the argument that TFIIB is the target of VP16 and insights into the energetic role of ATP in RNA polymerase II initiation.

Original languageEnglish (US)
Pages (from-to)236-244
Number of pages9
JournalCurrent Opinion in Genetics and Development
Volume4
Issue number2
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Transcription Factor TFIIA
TATA-Binding Protein Associated Factors
Transcription Factor TFIIB
RNA Polymerase II
Transcriptional Activation
Adenosine Triphosphate
Yeasts

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

Cite this

The role of activators in assembly of RNA polymerase II transcription complexes. / Hori, Roderick; Carey, Michael.

In: Current Opinion in Genetics and Development, Vol. 4, No. 2, 01.01.1994, p. 236-244.

Research output: Contribution to journalArticle

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