The role of antiplatelet drugs in carotid reconstructive surgery

William Edwards, W. H. Edwards, J. L. Mulherin, J. M. Jenkins

    Research output: Contribution to journalArticle

    15 Citations (Scopus)

    Abstract

    Neurologic events following carotid reconstructive surgery for symptomatic cerebral occlusive disease are generally reported to be one to two per cent. One of the events leading to this incidence is thrombosis of the endarterectomized internal carotid artery (ICA) after surgery. Since antiplatelet drugs have been found to be effective in altering platelet-induced thrombosis, we undertook a clinical trial of administration of aspirin (or aspirin-like) drugs to a group of patiets who were to undergo ICA endarterectomy. This group was then compared to a comparable group from the previous year in whom drugs had not been administered. Thrombosis resulting in hemiparesis occurred on six occasions in five patients in the group that did not receive drugs. Thrombosis was not observed in two patients exhibiting hemiparesis in the drugs group. On the basis of these results, we concluded that the incidence of neurological complications following carotid reconstructive surgery can be further reduced by the use of aspirin and aspirin-like drugs.

    Original languageEnglish (US)
    Pages (from-to)765-770
    Number of pages6
    JournalAnnals of surgery
    Volume201
    Issue number6
    DOIs
    StatePublished - Jan 1 1985

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    Reconstructive Surgical Procedures
    Platelet Aggregation Inhibitors
    Aspirin
    Thrombosis
    Pharmaceutical Preparations
    Paresis
    Carotid Artery Thrombosis
    Carotid Endarterectomy
    Incidence
    Internal Carotid Artery
    Nervous System
    Blood Platelets
    Clinical Trials

    All Science Journal Classification (ASJC) codes

    • Surgery

    Cite this

    Edwards, W., Edwards, W. H., Mulherin, J. L., & Jenkins, J. M. (1985). The role of antiplatelet drugs in carotid reconstructive surgery. Annals of surgery, 201(6), 765-770. https://doi.org/10.1097/00000658-198506000-00014

    The role of antiplatelet drugs in carotid reconstructive surgery. / Edwards, William; Edwards, W. H.; Mulherin, J. L.; Jenkins, J. M.

    In: Annals of surgery, Vol. 201, No. 6, 01.01.1985, p. 765-770.

    Research output: Contribution to journalArticle

    Edwards, W, Edwards, WH, Mulherin, JL & Jenkins, JM 1985, 'The role of antiplatelet drugs in carotid reconstructive surgery', Annals of surgery, vol. 201, no. 6, pp. 765-770. https://doi.org/10.1097/00000658-198506000-00014
    Edwards, William ; Edwards, W. H. ; Mulherin, J. L. ; Jenkins, J. M. / The role of antiplatelet drugs in carotid reconstructive surgery. In: Annals of surgery. 1985 ; Vol. 201, No. 6. pp. 765-770.
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