The role of autosomal cell apoptosis regulator genes in human spermatogenesis

W. W. Lin, D. J. Lamb, L. I. Lipshultz, Edward Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Immunohistochemical analysis of the expression of the autosomal apoptosis regulator genes, BAX, bcl-2, p53, and cyclic-AMP responsive element modulator (CREM) in testis biopsies from infertile men demonstrated that BAX, bcl-2, and p53 immunoreactivity was absent irrespective of seminiferous tubule histology. In contrast, cell-specific CREM immunoreactivity in round spermatids, with complete absence of CREM in patient biopsies showing spermatocyte maturation arrest and Sertoli cell only, was evident, suggesting a possible role of autosomal genes in the regulation of apoptosis in human spermatogenesis regulation.

Original languageEnglish (US)
Pages (from-to)237-246
Number of pages10
JournalInternational Urology and Nephrology
Volume31
Issue number2
DOIs
StatePublished - Sep 8 1999
Externally publishedYes

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Spermatogenesis
Regulator Genes
Cyclic AMP
Apoptosis
Biopsy
Seminiferous Tubules
Spermatocytes
Spermatids
Sertoli Cells
Testis
Histology
Genes

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Urology

Cite this

The role of autosomal cell apoptosis regulator genes in human spermatogenesis. / Lin, W. W.; Lamb, D. J.; Lipshultz, L. I.; Kim, Edward.

In: International Urology and Nephrology, Vol. 31, No. 2, 08.09.1999, p. 237-246.

Research output: Contribution to journalArticle

Lin, W. W. ; Lamb, D. J. ; Lipshultz, L. I. ; Kim, Edward. / The role of autosomal cell apoptosis regulator genes in human spermatogenesis. In: International Urology and Nephrology. 1999 ; Vol. 31, No. 2. pp. 237-246.
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