The role of collagen abnormalities in ultrasound and densitometry assessment

In vivo evidence

S. Cheng, Frances Tylavsky, E. S. Orwoll, J. Y. Rho, L. D. Carbone

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

There is little information concerning how the mutation of collagen affects bone mineralization and the assessment of bone properties. To estimate these influences, we performed ultrasonic assessments of the calcaneus and bone mineral density (BMD) measurements of the hip and lumbar spine. Females with diseases related to the mutation of collagen [Ehlers- Danlos syndrome (EDS) type III and systemic sclerosis (SSc)] participated in this study. We compared the broadband ultrasound attenuation (BUA and UBI- 4), the average transit time through the heel (TTH), and a multiple factor index (UBI-4T) with control subjects matched on age, race, and menstrual status. Both groups of patients had BMD of the spine (L2-L4) within the normal range for their age and sex (for EDS: n = 23, 1.14 ± 0.14 g/cm2 and z-score = 0.37; for SSc: n = 15, 0.98 ± 0.15 g/cm2 and z-score = 0.20). EDS and SSc subjects had lower BMD of the femoral neck (FN) compared with controls (for EDS: 0.91 ± 0.13 g/cm2, z-score = -0.41, P = 0.025; for SSc 0.67 ± 0.13 g/cm2, z-score = -0.92, P = 0.006). Subjects with EDS and SSc also had lower BUA values (P = 0.051-0.001) compared with controls. After adjusting for body weight, height, and the level of physical activity, the difference in FN BMD between EDS or SSc and controls became marginal (EDS: P = 0.072; SSc: P = 0.086). However, the significant difference for BUA between subjects and controls remained for EDS (P = 0.008), and disappeared for SSc (0.70) after adjusting for weight, height, level of physical activity, and BMD. These results suggest that the abnormalities of collagen may impact on bone mass measurements differently depending on skeletal site, modality of the assessment, and the source and nature of collagen defects. To determine whether collagen properties influence QUS, proper models in vivo and in vitro should be used.

Original languageEnglish (US)
Pages (from-to)470-476
Number of pages7
JournalCalcified Tissue International
Volume64
Issue number6
DOIs
StatePublished - 1999

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Ehlers-Danlos Syndrome
Densitometry
Systemic Scleroderma
Collagen
Bone Density
Femur Neck
Spine
Exercise
Bone and Bones
Physiologic Calcification
Calcaneus
Mutation
Body Height
Heel
Ultrasonics
Hip
Reference Values
Body Weight
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Endocrinology

Cite this

The role of collagen abnormalities in ultrasound and densitometry assessment : In vivo evidence. / Cheng, S.; Tylavsky, Frances; Orwoll, E. S.; Rho, J. Y.; Carbone, L. D.

In: Calcified Tissue International, Vol. 64, No. 6, 1999, p. 470-476.

Research output: Contribution to journalArticle

Cheng, S. ; Tylavsky, Frances ; Orwoll, E. S. ; Rho, J. Y. ; Carbone, L. D. / The role of collagen abnormalities in ultrasound and densitometry assessment : In vivo evidence. In: Calcified Tissue International. 1999 ; Vol. 64, No. 6. pp. 470-476.
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