The role of CpG dinucleotides in DNA vaccines

Arthur M. Krieg, Ae-Kyung Yi, Joachim Schorr, Heather L. Davis

Research output: Contribution to journalReview article

215 Citations (Scopus)

Abstract

DNA vaccines can induce potent humoral and cellular immune responses without any additional adjuvant. Recent studies indicate that unmethylated CpG dinucleotides within DNA vaccines are immune stimulatory and exert an essential endogenous adjuvant activity. These CpG motifs can be added deliberately to DNA or conventional protein vaccines to enhance the Th1 immune response.

Original languageEnglish (US)
Pages (from-to)23-27
Number of pages5
JournalTrends in Microbiology
Volume6
Issue number1
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

Fingerprint

DNA Vaccines
Humoral Immunity
Cellular Immunity
Vaccines
DNA
Proteins

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

Cite this

The role of CpG dinucleotides in DNA vaccines. / Krieg, Arthur M.; Yi, Ae-Kyung; Schorr, Joachim; Davis, Heather L.

In: Trends in Microbiology, Vol. 6, No. 1, 01.01.1998, p. 23-27.

Research output: Contribution to journalReview article

Krieg, Arthur M. ; Yi, Ae-Kyung ; Schorr, Joachim ; Davis, Heather L. / The role of CpG dinucleotides in DNA vaccines. In: Trends in Microbiology. 1998 ; Vol. 6, No. 1. pp. 23-27.
@article{761d050394ac42c2b2f38bc63d1d5d12,
title = "The role of CpG dinucleotides in DNA vaccines",
abstract = "DNA vaccines can induce potent humoral and cellular immune responses without any additional adjuvant. Recent studies indicate that unmethylated CpG dinucleotides within DNA vaccines are immune stimulatory and exert an essential endogenous adjuvant activity. These CpG motifs can be added deliberately to DNA or conventional protein vaccines to enhance the Th1 immune response.",
author = "Krieg, {Arthur M.} and Ae-Kyung Yi and Joachim Schorr and Davis, {Heather L.}",
year = "1998",
month = "1",
day = "1",
doi = "10.1016/S0966-842X(97)01145-1",
language = "English (US)",
volume = "6",
pages = "23--27",
journal = "Trends in Microbiology",
issn = "0966-842X",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - The role of CpG dinucleotides in DNA vaccines

AU - Krieg, Arthur M.

AU - Yi, Ae-Kyung

AU - Schorr, Joachim

AU - Davis, Heather L.

PY - 1998/1/1

Y1 - 1998/1/1

N2 - DNA vaccines can induce potent humoral and cellular immune responses without any additional adjuvant. Recent studies indicate that unmethylated CpG dinucleotides within DNA vaccines are immune stimulatory and exert an essential endogenous adjuvant activity. These CpG motifs can be added deliberately to DNA or conventional protein vaccines to enhance the Th1 immune response.

AB - DNA vaccines can induce potent humoral and cellular immune responses without any additional adjuvant. Recent studies indicate that unmethylated CpG dinucleotides within DNA vaccines are immune stimulatory and exert an essential endogenous adjuvant activity. These CpG motifs can be added deliberately to DNA or conventional protein vaccines to enhance the Th1 immune response.

UR - http://www.scopus.com/inward/record.url?scp=0031891451&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031891451&partnerID=8YFLogxK

U2 - 10.1016/S0966-842X(97)01145-1

DO - 10.1016/S0966-842X(97)01145-1

M3 - Review article

VL - 6

SP - 23

EP - 27

JO - Trends in Microbiology

JF - Trends in Microbiology

SN - 0966-842X

IS - 1

ER -