The role of extracellular matrix in postinflammatory wound healing and fibrosis

Research output: Contribution to journalReview article

337 Citations (Scopus)

Abstract

Massive cell migration, proliferation, phenotypic differentiation, and enhanced biosynthetic activities characterize the sites of wound healing and fibrosis. Regulation of cellular functions by extracellular matrix, which consists of a dynamic assemblage of a variety of interacting molecules capable of reorganization in response to endogenous and exogenous stimuli, represents a fundamental epigenetic mechanism regulating cellular behavior and phenotype. Interactions of the individual components of extracellular matrix with specific cell surface molecules, integrin receptors, and proteoglycans initiate a cascade of signal transduction leading to varied short-term or persistent cellular responses. Extracellular matrix also serves as an important reservoir of cytokines and growth factors, thus modulating the action of a host of potent biological response modifiers by their selective, local accumulation and release. Currently known mechanisms by which extracellular matrix modulates different facets of the process of tissue remodeling after injury, which culminate either in normal wound repair or fibrosis, are discussed.

Original languageEnglish (US)
Pages (from-to)823-831
Number of pages9
JournalFASEB Journal
Volume8
Issue number11
StatePublished - Aug 31 1994

Fingerprint

Wound Healing
Extracellular Matrix
Fibrosis
Signal transduction
Molecules
Wounds and Injuries
Immunologic Factors
Proteoglycans
Epigenomics
Integrins
Cell Movement
Signal Transduction
Intercellular Signaling Peptides and Proteins
Repair
Cell Proliferation
Tissue
Cytokines
Phenotype

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

The role of extracellular matrix in postinflammatory wound healing and fibrosis. / Raghow, Rajendra.

In: FASEB Journal, Vol. 8, No. 11, 31.08.1994, p. 823-831.

Research output: Contribution to journalReview article

@article{d5fa8497f5904a7bac1cd54ebaee5969,
title = "The role of extracellular matrix in postinflammatory wound healing and fibrosis",
abstract = "Massive cell migration, proliferation, phenotypic differentiation, and enhanced biosynthetic activities characterize the sites of wound healing and fibrosis. Regulation of cellular functions by extracellular matrix, which consists of a dynamic assemblage of a variety of interacting molecules capable of reorganization in response to endogenous and exogenous stimuli, represents a fundamental epigenetic mechanism regulating cellular behavior and phenotype. Interactions of the individual components of extracellular matrix with specific cell surface molecules, integrin receptors, and proteoglycans initiate a cascade of signal transduction leading to varied short-term or persistent cellular responses. Extracellular matrix also serves as an important reservoir of cytokines and growth factors, thus modulating the action of a host of potent biological response modifiers by their selective, local accumulation and release. Currently known mechanisms by which extracellular matrix modulates different facets of the process of tissue remodeling after injury, which culminate either in normal wound repair or fibrosis, are discussed.",
author = "Rajendra Raghow",
year = "1994",
month = "8",
day = "31",
language = "English (US)",
volume = "8",
pages = "823--831",
journal = "FASEB Journal",
issn = "0892-6638",
publisher = "FASEB",
number = "11",

}

TY - JOUR

T1 - The role of extracellular matrix in postinflammatory wound healing and fibrosis

AU - Raghow, Rajendra

PY - 1994/8/31

Y1 - 1994/8/31

N2 - Massive cell migration, proliferation, phenotypic differentiation, and enhanced biosynthetic activities characterize the sites of wound healing and fibrosis. Regulation of cellular functions by extracellular matrix, which consists of a dynamic assemblage of a variety of interacting molecules capable of reorganization in response to endogenous and exogenous stimuli, represents a fundamental epigenetic mechanism regulating cellular behavior and phenotype. Interactions of the individual components of extracellular matrix with specific cell surface molecules, integrin receptors, and proteoglycans initiate a cascade of signal transduction leading to varied short-term or persistent cellular responses. Extracellular matrix also serves as an important reservoir of cytokines and growth factors, thus modulating the action of a host of potent biological response modifiers by their selective, local accumulation and release. Currently known mechanisms by which extracellular matrix modulates different facets of the process of tissue remodeling after injury, which culminate either in normal wound repair or fibrosis, are discussed.

AB - Massive cell migration, proliferation, phenotypic differentiation, and enhanced biosynthetic activities characterize the sites of wound healing and fibrosis. Regulation of cellular functions by extracellular matrix, which consists of a dynamic assemblage of a variety of interacting molecules capable of reorganization in response to endogenous and exogenous stimuli, represents a fundamental epigenetic mechanism regulating cellular behavior and phenotype. Interactions of the individual components of extracellular matrix with specific cell surface molecules, integrin receptors, and proteoglycans initiate a cascade of signal transduction leading to varied short-term or persistent cellular responses. Extracellular matrix also serves as an important reservoir of cytokines and growth factors, thus modulating the action of a host of potent biological response modifiers by their selective, local accumulation and release. Currently known mechanisms by which extracellular matrix modulates different facets of the process of tissue remodeling after injury, which culminate either in normal wound repair or fibrosis, are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0027939832&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027939832&partnerID=8YFLogxK

M3 - Review article

VL - 8

SP - 823

EP - 831

JO - FASEB Journal

JF - FASEB Journal

SN - 0892-6638

IS - 11

ER -