The role of immunohistochemistry in the diagnosis of urinary bladder neoplasms

Jesse K. McKenney, Mahul Amin

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The spectrum of neoplasms involving the urinary bladder is diverse, and, at times, different entities with distinct prognostic and managerial implications may have significant morphologic overlap. The presence of a neoplasm with an unusual morphologic appearance, such as an undifferentiated spindled, or plasmacytoid pattern may necessitate immunohistochemistry to establish the diagnosis. In this review, we discuss a series of distinct diagnostic scenarios, including high-grade undifferentiated carcinoma versus prostatic adenocarcinoma, enteric-type adenocarcinoma versus secondary colorectal adenocarcinoma, spindle cell proliferations, neoplasms with plasmacytoid morphology, endophytic tumors with a nested growth pattern, and flat urothelial lesions with atypia. We also discuss markers supporting urothelial differentiation in the context of a metastatic carcinoma from an unknown primary. The importance of using a morphologically derived differential diagnosis to guide the selection and interpretation of immunohistochemical studies is emphasized, and the varying utility (specificity) of the individual immunohistochemical markers within each setting is addressed.

Original languageEnglish (US)
Pages (from-to)69-87
Number of pages19
JournalSeminars in Diagnostic Pathology
Volume22
Issue number1
DOIs
StatePublished - Jan 1 2005

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Urinary Bladder Neoplasms
Adenocarcinoma
Immunohistochemistry
Carcinoma
Neoplasms
Differential Diagnosis
Cell Proliferation
Growth

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

The role of immunohistochemistry in the diagnosis of urinary bladder neoplasms. / McKenney, Jesse K.; Amin, Mahul.

In: Seminars in Diagnostic Pathology, Vol. 22, No. 1, 01.01.2005, p. 69-87.

Research output: Contribution to journalArticle

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