The Role of MIR-21 in Cancer

Susan R. Pfeffer, Chuan Yang, Lawrence Pfeffer

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Preclinical Research MicroRNAs (miRNAs) are small endogenous noncoding RNAs that suppress gene expression at the post-transcriptional level. In the past decade, miRNAs have been extensively studied in a number of different human cancers. MiRNAs have been identified to act both as oncogenes and as tumor suppressors. In addition, miRNAs are associated with the intrinsic resistance of cancer to various forms of therapy, and they are implicated in both tumor progression and metastasis. The characterization of the specific alterations in the patterns of miRNA expression in cancer has great potential for identifying biomarkers for early cancer detection, as well as for potential therapeutic intervention in cancer treatment. In this chapter, we describe the ever-expanding role of miR-21 and its target genes in different cancers, and provide insight into how this oncogenic miRNA regulates cancer cell proliferation, migration, and apoptosis by suppressing the expression of tumor suppressors.

Original languageEnglish (US)
Pages (from-to)270-277
Number of pages8
JournalDrug Development Research
Volume76
Issue number6
DOIs
StatePublished - Sep 1 2015

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MicroRNAs
Neoplasms
Small Untranslated RNA
Oncogenes
Early Detection of Cancer
Cell Movement
Biomarkers
Cell Proliferation
Apoptosis
Neoplasm Metastasis
Gene Expression
Therapeutics
Research
Genes

All Science Journal Classification (ASJC) codes

  • Drug Discovery

Cite this

The Role of MIR-21 in Cancer. / Pfeffer, Susan R.; Yang, Chuan; Pfeffer, Lawrence.

In: Drug Development Research, Vol. 76, No. 6, 01.09.2015, p. 270-277.

Research output: Contribution to journalArticle

Pfeffer, Susan R. ; Yang, Chuan ; Pfeffer, Lawrence. / The Role of MIR-21 in Cancer. In: Drug Development Research. 2015 ; Vol. 76, No. 6. pp. 270-277.
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