The Role of Nonalcoholic Fatty Liver Disease on Cardiovascular Manifestations and Outcomes

Alexander J. Kovalic, Sanjaya Satapathy

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Cardiovascular disease has been postulated as the leading cause of mortality among patients with nonalcoholic fatty liver disease (NAFLD), rather than from sequalae of liver disease specifically. While there is ample evidence validating the association between NAFLD and increased cardiovascular comorbidities, events, and mortality, current data presents a challenge in attributing this effect solely due to NAFLD given the rampant presence of insulin resistance and type 2 diabetes mellitus (T2DM). Endpoints of increased cardiovascular risk remains tightly linked to the concomitant presence of insulin resistance and T2DM. Prospective studies accentuating early detection of NAFLD are imperative to institute early intervention and prevent future cardiovascular events.

Original languageEnglish (US)
Pages (from-to)141-174
Number of pages34
JournalClinics in Liver Disease
Volume22
Issue number1
DOIs
StatePublished - Feb 1 2018

Fingerprint

Type 2 Diabetes Mellitus
Insulin Resistance
Mortality
Comorbidity
Liver Diseases
Cardiovascular Diseases
Prospective Studies
Non-alcoholic Fatty Liver Disease

All Science Journal Classification (ASJC) codes

  • Hepatology

Cite this

The Role of Nonalcoholic Fatty Liver Disease on Cardiovascular Manifestations and Outcomes. / Kovalic, Alexander J.; Satapathy, Sanjaya.

In: Clinics in Liver Disease, Vol. 22, No. 1, 01.02.2018, p. 141-174.

Research output: Contribution to journalReview article

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