The role of nuclear factor κb in the interferon response

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

The nuclear factor κB (NF-κB) transcription factor regulates the expression of genes involved in cell survival and immune responses. We have identified a novel interferon (IFN)-activated signaling pathway that leads to NF-κB activation and demonstrate that a subset of IFN-stimulated genes and microRNAs that play key roles in cellular response to IFN is regulated by NF-κB. This review focuses on the IFN-induced NF-κB activation pathway and the role of NF-κB in the expression of IFN-induced coding and noncoding genes, antiviral activity and apoptosis, and the therapeutic application of IFN in cancer and infectious disease.

Original languageEnglish (US)
Pages (from-to)553-559
Number of pages7
JournalJournal of Interferon and Cytokine Research
Volume31
Issue number7
DOIs
StatePublished - Jul 1 2011

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Interferons
MicroRNAs
Genes
Antiviral Agents
Communicable Diseases
Cell Survival
Transcription Factors
Apoptosis
Gene Expression
Neoplasms

All Science Journal Classification (ASJC) codes

  • Immunology
  • Cell Biology
  • Virology

Cite this

The role of nuclear factor κb in the interferon response. / Pfeffer, Lawrence.

In: Journal of Interferon and Cytokine Research, Vol. 31, No. 7, 01.07.2011, p. 553-559.

Research output: Contribution to journalReview article

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