The role of proton pump inhibitors in the management of upper gastrointestinal disorders

Muhammad Ali Khan, Colin Howden

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Proton pump inhibitors (PPIs) have been in use since the early 1990s and play a crucial role in the management of a number of conditions affecting the upper gastrointestinal tract, including gastroesophageal reflux disease, Barrett esophagus, eosinophilic esophagitis, and dyspepsia. PPIs also play an important role in the treatment of Helicobacter pylori infection and in the prevention of upper gastrointestinal tract ulcers and bleeding among patients taking antiplatelet therapy and/or nonsteroidal antiinflammatory drugs. Despite recent concerns regarding the longterm safety of PPIs, their riskbenefit profiles strongly favor their appropriate use in patients who have genuine indications for them. As with all drugs, PPIs should be administered in the lowest effective dose and only for as long as clinically indicated. However, for at least some of their approved indications, PPIs are likely to be required indefinitely. This article outlines the current indications for PPIs for the management of upper gastrointestinal disorders and reviews safety concerns.

Original languageEnglish (US)
Pages (from-to)169-175
Number of pages7
JournalGastroenterology and Hepatology
Volume14
Issue number3
StatePublished - Mar 1 2018

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Proton Pump Inhibitors
Upper Gastrointestinal Tract
Eosinophilic Esophagitis
Safety
Barrett Esophagus
Dyspepsia
Helicobacter Infections
Gastroesophageal Reflux
Helicobacter pylori
Pharmaceutical Preparations
Ulcer
Anti-Inflammatory Agents
Hemorrhage
Therapeutics

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

The role of proton pump inhibitors in the management of upper gastrointestinal disorders. / Khan, Muhammad Ali; Howden, Colin.

In: Gastroenterology and Hepatology, Vol. 14, No. 3, 01.03.2018, p. 169-175.

Research output: Contribution to journalArticle

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