The role of the membrane skeleton in formation of the irreversibly sickled cell

A review

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In this review we discuss the evidence in support of the concept that a posttranslational modification in β-actin, in which a disulfide bridge is formed between cysteine284 and cysteine373, is the major cause of the formation of the irreversibly sickled cell (ISC). This ISC β-actin modification caused a decreased ability of the ISC membrane skeletal proteins to disassemble, as compared to the control and reversible sickled cell (RSC) membrane skeleton, because of altered actin filament formation. The slow disassembly of the ISC membrane skeleton proteins gives a reasonable explanation for the inability of the ISC to remodel its shape. An understanding of the molecular basis of the irreversibly sickled cells formation has helped initiate a rationale for development of drugs to block ISC formation in vivo.

Original languageEnglish (US)
Pages (from-to)105-112
Number of pages8
JournalCellular and Molecular Biology Letters
Volume1
Issue number1
StatePublished - Jan 1 1996
Externally publishedYes

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Cell membranes
Skeleton
Actins
Membranes
Membrane Proteins
Disulfides
Proteins
Post Translational Protein Processing
Actin Cytoskeleton
Pharmaceutical Preparations
Cell Membrane

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

The role of the membrane skeleton in formation of the irreversibly sickled cell : A review. / Goodman, Steven.

In: Cellular and Molecular Biology Letters, Vol. 1, No. 1, 01.01.1996, p. 105-112.

Research output: Contribution to journalArticle

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