The role of the newer antiepileptic drugs in the treatment of generalized convulsive status epilepticus

James Wheless, David M. Treiman

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

The emergency treatment of seizures is an important practical issue, especially the treatment of generalized convulsive status epilepticus (GCSE). Benzodiazepines or older standard antiepileptic drugs (phenobarbital, phenytoin) have typically been used as initial intravenous treatment of GCSE. As new parenteral antiepileptic drugs are developed, and more are on the horizon, questions are raised regarding their role in the treatment of status epilepticus (SE). This review discusses the evidence for the treatment of GCSE, including the newer agents (valproate, levetiracetam). We correlate the treatment of SE with our modern understanding of the underlying neurophysiology and seizure duration.

Original languageEnglish (US)
Pages (from-to)74-78
Number of pages5
JournalEpilepsia
Volume49
Issue numberSUPPL. 9
DOIs
StatePublished - Dec 1 2008

Fingerprint

Status Epilepticus
Anticonvulsants
etiracetam
Seizures
Therapeutics
Neurophysiology
Emergency Treatment
Valproic Acid
Phenytoin
Phenobarbital
Benzodiazepines

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

The role of the newer antiepileptic drugs in the treatment of generalized convulsive status epilepticus. / Wheless, James; Treiman, David M.

In: Epilepsia, Vol. 49, No. SUPPL. 9, 01.12.2008, p. 74-78.

Research output: Contribution to journalReview article

@article{e65c5803d199407b9c000004de585cff,
title = "The role of the newer antiepileptic drugs in the treatment of generalized convulsive status epilepticus",
abstract = "The emergency treatment of seizures is an important practical issue, especially the treatment of generalized convulsive status epilepticus (GCSE). Benzodiazepines or older standard antiepileptic drugs (phenobarbital, phenytoin) have typically been used as initial intravenous treatment of GCSE. As new parenteral antiepileptic drugs are developed, and more are on the horizon, questions are raised regarding their role in the treatment of status epilepticus (SE). This review discusses the evidence for the treatment of GCSE, including the newer agents (valproate, levetiracetam). We correlate the treatment of SE with our modern understanding of the underlying neurophysiology and seizure duration.",
author = "James Wheless and Treiman, {David M.}",
year = "2008",
month = "12",
day = "1",
doi = "10.1111/j.1528-1167.2008.01929.x",
language = "English (US)",
volume = "49",
pages = "74--78",
journal = "Epilepsia",
issn = "0013-9580",
publisher = "Wiley-Blackwell",
number = "SUPPL. 9",

}

TY - JOUR

T1 - The role of the newer antiepileptic drugs in the treatment of generalized convulsive status epilepticus

AU - Wheless, James

AU - Treiman, David M.

PY - 2008/12/1

Y1 - 2008/12/1

N2 - The emergency treatment of seizures is an important practical issue, especially the treatment of generalized convulsive status epilepticus (GCSE). Benzodiazepines or older standard antiepileptic drugs (phenobarbital, phenytoin) have typically been used as initial intravenous treatment of GCSE. As new parenteral antiepileptic drugs are developed, and more are on the horizon, questions are raised regarding their role in the treatment of status epilepticus (SE). This review discusses the evidence for the treatment of GCSE, including the newer agents (valproate, levetiracetam). We correlate the treatment of SE with our modern understanding of the underlying neurophysiology and seizure duration.

AB - The emergency treatment of seizures is an important practical issue, especially the treatment of generalized convulsive status epilepticus (GCSE). Benzodiazepines or older standard antiepileptic drugs (phenobarbital, phenytoin) have typically been used as initial intravenous treatment of GCSE. As new parenteral antiepileptic drugs are developed, and more are on the horizon, questions are raised regarding their role in the treatment of status epilepticus (SE). This review discusses the evidence for the treatment of GCSE, including the newer agents (valproate, levetiracetam). We correlate the treatment of SE with our modern understanding of the underlying neurophysiology and seizure duration.

UR - http://www.scopus.com/inward/record.url?scp=57249103572&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57249103572&partnerID=8YFLogxK

U2 - 10.1111/j.1528-1167.2008.01929.x

DO - 10.1111/j.1528-1167.2008.01929.x

M3 - Review article

C2 - 19087120

AN - SCOPUS:57249103572

VL - 49

SP - 74

EP - 78

JO - Epilepsia

JF - Epilepsia

SN - 0013-9580

IS - SUPPL. 9

ER -