The role of the nucleus accumbens in sensitization to drugs of abuse

Jeffery Steketee, Barbara A. Sorg, Peter W. Kalivas

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

1. 1. Male rats received cannula implants above the nucleus accumbens for monitoring extracellular concentrations of dopamine via in vivo microdialysis. 2. 2. Daily injections with cocaine led to an augmentation in both the behavioral response and the neurochemical response (i.e. cocaine-induced increase in extracellular dopamine within the nucleus accumbens) to this drug. 3. 3. Pertussis toxin injections into the A10 region led to sensitized behavioral and neurochemical responses to an acute injection of cocaine. 4. 4. Prior exposure to footshock stress augmented the cocaine-induced increase of motor activity and of extracellular dopamine within the nucleus accumbens. 5. 5. These data suggest that treatments which lead to behavioral sensitization also lead to sensitization within the mesolimbic dopamine system as measured by an augmented dopamine release in the nucleus accumbens.

Original languageEnglish (US)
Pages (from-to)237-246
Number of pages10
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Volume16
Issue number2
DOIs
StatePublished - Jan 1 1992

Fingerprint

Nucleus Accumbens
Street Drugs
Dopamine
Cocaine
Injections
antineoplaston A10
Pertussis Toxin
Microdialysis
Motor Activity
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Biological Psychiatry

Cite this

The role of the nucleus accumbens in sensitization to drugs of abuse. / Steketee, Jeffery; Sorg, Barbara A.; Kalivas, Peter W.

In: Progress in Neuropsychopharmacology and Biological Psychiatry, Vol. 16, No. 2, 01.01.1992, p. 237-246.

Research output: Contribution to journalArticle

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