The role of tissue microarrays in prostate cancer biomarker discovery

Milton W. Datta, Lawrence D. True, Peter S. Nelson, Mahul Amin

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Tissue microarrays (TMAs) offer the potential to rapidly translate genomics and basic science research findings to practical clinical application. This is particularly true in the field of cancer biomarker research, where TMAs can be used for candidate biomarker validation and association with patient clinical, pathologic, and outcomes parameters. In this review, we examine the effect of TMA use on prostate cancer biomarker research, focusing on the types of TMAs that have been used, and the biomarkers that have been examined. The results demonstrate that TMAs have been very effective in screening candidate biomarkers for subsequent, extended evaluation in large patient populations. In addition, the use of TMAs in multiple biomarker series allows for the statistical analysis of sets of biomarkers as diagnostic or prognostic tests. The processes used here can be applied to any tumor type to improve patient diagnosis, prognosis, and treatment response prediction.

Original languageEnglish (US)
Pages (from-to)408-418
Number of pages11
JournalAdvances in anatomic pathology
Volume14
Issue number6
DOIs
StatePublished - Nov 1 2007

Fingerprint

Tumor Biomarkers
Prostatic Neoplasms
Biomarkers
Research
Genomics
Population
Neoplasms

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

The role of tissue microarrays in prostate cancer biomarker discovery. / Datta, Milton W.; True, Lawrence D.; Nelson, Peter S.; Amin, Mahul.

In: Advances in anatomic pathology, Vol. 14, No. 6, 01.11.2007, p. 408-418.

Research output: Contribution to journalReview article

Datta, Milton W. ; True, Lawrence D. ; Nelson, Peter S. ; Amin, Mahul. / The role of tissue microarrays in prostate cancer biomarker discovery. In: Advances in anatomic pathology. 2007 ; Vol. 14, No. 6. pp. 408-418.
@article{8a2804106e154a5eb59b6184036505e1,
title = "The role of tissue microarrays in prostate cancer biomarker discovery",
abstract = "Tissue microarrays (TMAs) offer the potential to rapidly translate genomics and basic science research findings to practical clinical application. This is particularly true in the field of cancer biomarker research, where TMAs can be used for candidate biomarker validation and association with patient clinical, pathologic, and outcomes parameters. In this review, we examine the effect of TMA use on prostate cancer biomarker research, focusing on the types of TMAs that have been used, and the biomarkers that have been examined. The results demonstrate that TMAs have been very effective in screening candidate biomarkers for subsequent, extended evaluation in large patient populations. In addition, the use of TMAs in multiple biomarker series allows for the statistical analysis of sets of biomarkers as diagnostic or prognostic tests. The processes used here can be applied to any tumor type to improve patient diagnosis, prognosis, and treatment response prediction.",
author = "Datta, {Milton W.} and True, {Lawrence D.} and Nelson, {Peter S.} and Mahul Amin",
year = "2007",
month = "11",
day = "1",
doi = "10.1097/PAP.0b013e318155709a",
language = "English (US)",
volume = "14",
pages = "408--418",
journal = "Advances in Anatomic Pathology",
issn = "1072-4109",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - The role of tissue microarrays in prostate cancer biomarker discovery

AU - Datta, Milton W.

AU - True, Lawrence D.

AU - Nelson, Peter S.

AU - Amin, Mahul

PY - 2007/11/1

Y1 - 2007/11/1

N2 - Tissue microarrays (TMAs) offer the potential to rapidly translate genomics and basic science research findings to practical clinical application. This is particularly true in the field of cancer biomarker research, where TMAs can be used for candidate biomarker validation and association with patient clinical, pathologic, and outcomes parameters. In this review, we examine the effect of TMA use on prostate cancer biomarker research, focusing on the types of TMAs that have been used, and the biomarkers that have been examined. The results demonstrate that TMAs have been very effective in screening candidate biomarkers for subsequent, extended evaluation in large patient populations. In addition, the use of TMAs in multiple biomarker series allows for the statistical analysis of sets of biomarkers as diagnostic or prognostic tests. The processes used here can be applied to any tumor type to improve patient diagnosis, prognosis, and treatment response prediction.

AB - Tissue microarrays (TMAs) offer the potential to rapidly translate genomics and basic science research findings to practical clinical application. This is particularly true in the field of cancer biomarker research, where TMAs can be used for candidate biomarker validation and association with patient clinical, pathologic, and outcomes parameters. In this review, we examine the effect of TMA use on prostate cancer biomarker research, focusing on the types of TMAs that have been used, and the biomarkers that have been examined. The results demonstrate that TMAs have been very effective in screening candidate biomarkers for subsequent, extended evaluation in large patient populations. In addition, the use of TMAs in multiple biomarker series allows for the statistical analysis of sets of biomarkers as diagnostic or prognostic tests. The processes used here can be applied to any tumor type to improve patient diagnosis, prognosis, and treatment response prediction.

UR - http://www.scopus.com/inward/record.url?scp=37349007595&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37349007595&partnerID=8YFLogxK

U2 - 10.1097/PAP.0b013e318155709a

DO - 10.1097/PAP.0b013e318155709a

M3 - Review article

VL - 14

SP - 408

EP - 418

JO - Advances in Anatomic Pathology

JF - Advances in Anatomic Pathology

SN - 1072-4109

IS - 6

ER -