The roles of vitamin D and its analogs in inflammatory diseases

Zongtao Lin, Wei Li

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The discovery of nonclassical actions, other than mineral homeostasis, of 1α,25- dihydroxyvitamin D3 (1,25D3) has expanded its applications. Among these, its anti-inflammation activity has drawn more and more attention of researchers to investigate its role in regulating the progression of inflammatory diseases. The expression of many inflammation-related genes is regulated by 1,25D3 through vitamin D receptor (VDR) in a large variety of cells including immune cells such as, but not limited to, macrophages, dendritic cells, T helper cells, and B cells. Studies of 1,25D3 in these immune cells have shown both direct and indirect immunomodulatory activities affecting innate and adaptive immune responses. Moreover, 1,25D3 can also exert its anti-inflammation effects through regulating the biosynthesis of pro-inflammatory molecules in the prostaglandin pathway or through nuclear factor kappa light-chain-enhancer of activated B cells (NFκB) by affecting cytokine production and inflammatory responses. These actions of 1,25D3 may explain the associations between vitamin D levels and inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, asthma, type 1 diabetes, and systemic lupus erythematosus. Although several analogs of 1,25D3 have shown potent immunomodulatory or anti-inflammatory activity on immune cell cultures or in animal models, no vitamin D analog has been used in clinical research to treat inflammatory diseases. Here, we review the relationship between vitamin D analogs and inflammation based on observations of immune cells, prostaglandin and NFκB pathways, as well as common inflammatory diseases.

Original languageEnglish (US)
Pages (from-to)1242-1261
Number of pages20
JournalCurrent Topics in Medicinal Chemistry
Volume16
Issue number11
DOIs
StatePublished - May 1 2016

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Calcitriol
Vitamin D
Inflammation
Prostaglandins
B-Lymphocytes
Calcitriol Receptors
Adaptive Immunity
Helper-Inducer T-Lymphocytes
Type 1 Diabetes Mellitus
Inflammatory Bowel Diseases
Innate Immunity
Systemic Lupus Erythematosus
Dendritic Cells
Multiple Sclerosis
Minerals
Disease Progression
Rheumatoid Arthritis
Homeostasis
Anti-Inflammatory Agents
Asthma

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

The roles of vitamin D and its analogs in inflammatory diseases. / Lin, Zongtao; Li, Wei.

In: Current Topics in Medicinal Chemistry, Vol. 16, No. 11, 01.05.2016, p. 1242-1261.

Research output: Contribution to journalArticle

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