The search for promising viral targets in drug discovery

Colleen Jonsson, Lucile White, James Noah, William Severson, Marintha Heil

Research output: Contribution to journalArticle

Abstract

The activities described above give an introduction to the first phase of activity essential to drug discovery, and this is clearly just the beginning. Once a hit has been verified using a combination of cell-based and biochemical methods, we can move forward to determine the toxicity and efficacy of the drug in an animal model. It is after this stage that we will gain valuable insight into the suitability of the compound class for lead optimization medicinal chemistry and follow-up preclinical toxicology testing. It is hoped that recent advances in infrastructure, new assays, and HTS procedures will lead to the discovery of new antiviral drugs for emerging and reemerging pathogens, those of which we are aware and those that are yet to come.

Original languageEnglish (US)
Pages (from-to)18-21
Number of pages4
JournalAmerican Biotechnology Laboratory
Volume25
Issue number8
StatePublished - Aug 2007
Externally publishedYes

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Drug Discovery
Essential Drugs
Pharmaceutical Chemistry
Drug-Related Side Effects and Adverse Reactions
Toxicology
Antiviral Agents
Animal Models
Lead

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

Jonsson, C., White, L., Noah, J., Severson, W., & Heil, M. (2007). The search for promising viral targets in drug discovery. American Biotechnology Laboratory, 25(8), 18-21.

The search for promising viral targets in drug discovery. / Jonsson, Colleen; White, Lucile; Noah, James; Severson, William; Heil, Marintha.

In: American Biotechnology Laboratory, Vol. 25, No. 8, 08.2007, p. 18-21.

Research output: Contribution to journalArticle

Jonsson, C, White, L, Noah, J, Severson, W & Heil, M 2007, 'The search for promising viral targets in drug discovery', American Biotechnology Laboratory, vol. 25, no. 8, pp. 18-21.
Jonsson, Colleen ; White, Lucile ; Noah, James ; Severson, William ; Heil, Marintha. / The search for promising viral targets in drug discovery. In: American Biotechnology Laboratory. 2007 ; Vol. 25, No. 8. pp. 18-21.
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