The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis

Azadeh Golipour, Dorothy Myers, Tiffany Seagroves, Daniel Murphy, Gerard I. Evan, Daniel J. Donoghue, Roger A. Moorehead, Lisa A. Porter

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Spy1A is a unique cell cycle activator known to mediate cell cycle progression and override the DNA damage response. This study focused on determining the role of this protein on postnatal mammary gland morphogenesis and neoplasia. Herein, we show that Spy1A levels are tightly regulated during mammary gland development and that ectopic expression stimulates precocious development and results in disrupted morphology of the gland. This follows the same trend as the oncogene c-Myc, and we show that Spy1A expression is regulated downstream of c-Myc signaling. Importantly, we show that overexpression of Spy1A accelerates tumorigenesis in vivo. Collectively, this work is the first report that the Spy1/RINGO family of proteins may play an essential role in regulating both normal and abnormal growth processes in the breast.

Original languageEnglish (US)
Pages (from-to)3591-3600
Number of pages10
JournalCancer Research
Volume68
Issue number10
DOIs
StatePublished - May 15 2008

Fingerprint

Human Mammary Glands
Cell Cycle
Carcinogenesis
Breast
myc Genes
Growth
Morphogenesis
DNA Damage
Proteins
Neoplasms
Ectopic Gene Expression

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Golipour, A., Myers, D., Seagroves, T., Murphy, D., Evan, G. I., Donoghue, D. J., ... Porter, L. A. (2008). The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis. Cancer Research, 68(10), 3591-3600. https://doi.org/10.1158/0008-5472.CAN-07-6453

The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis. / Golipour, Azadeh; Myers, Dorothy; Seagroves, Tiffany; Murphy, Daniel; Evan, Gerard I.; Donoghue, Daniel J.; Moorehead, Roger A.; Porter, Lisa A.

In: Cancer Research, Vol. 68, No. 10, 15.05.2008, p. 3591-3600.

Research output: Contribution to journalArticle

Golipour, A, Myers, D, Seagroves, T, Murphy, D, Evan, GI, Donoghue, DJ, Moorehead, RA & Porter, LA 2008, 'The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis', Cancer Research, vol. 68, no. 10, pp. 3591-3600. https://doi.org/10.1158/0008-5472.CAN-07-6453
Golipour, Azadeh ; Myers, Dorothy ; Seagroves, Tiffany ; Murphy, Daniel ; Evan, Gerard I. ; Donoghue, Daniel J. ; Moorehead, Roger A. ; Porter, Lisa A. / The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis. In: Cancer Research. 2008 ; Vol. 68, No. 10. pp. 3591-3600.
@article{ea8111f1ed20449685ab15169f4938e5,
title = "The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis",
abstract = "Spy1A is a unique cell cycle activator known to mediate cell cycle progression and override the DNA damage response. This study focused on determining the role of this protein on postnatal mammary gland morphogenesis and neoplasia. Herein, we show that Spy1A levels are tightly regulated during mammary gland development and that ectopic expression stimulates precocious development and results in disrupted morphology of the gland. This follows the same trend as the oncogene c-Myc, and we show that Spy1A expression is regulated downstream of c-Myc signaling. Importantly, we show that overexpression of Spy1A accelerates tumorigenesis in vivo. Collectively, this work is the first report that the Spy1/RINGO family of proteins may play an essential role in regulating both normal and abnormal growth processes in the breast.",
author = "Azadeh Golipour and Dorothy Myers and Tiffany Seagroves and Daniel Murphy and Evan, {Gerard I.} and Donoghue, {Daniel J.} and Moorehead, {Roger A.} and Porter, {Lisa A.}",
year = "2008",
month = "5",
day = "15",
doi = "10.1158/0008-5472.CAN-07-6453",
language = "English (US)",
volume = "68",
pages = "3591--3600",
journal = "Journal of Cancer Research",
issn = "0099-7013",
publisher = "American Association for Cancer Research Inc.",
number = "10",

}

TY - JOUR

T1 - The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis

AU - Golipour, Azadeh

AU - Myers, Dorothy

AU - Seagroves, Tiffany

AU - Murphy, Daniel

AU - Evan, Gerard I.

AU - Donoghue, Daniel J.

AU - Moorehead, Roger A.

AU - Porter, Lisa A.

PY - 2008/5/15

Y1 - 2008/5/15

N2 - Spy1A is a unique cell cycle activator known to mediate cell cycle progression and override the DNA damage response. This study focused on determining the role of this protein on postnatal mammary gland morphogenesis and neoplasia. Herein, we show that Spy1A levels are tightly regulated during mammary gland development and that ectopic expression stimulates precocious development and results in disrupted morphology of the gland. This follows the same trend as the oncogene c-Myc, and we show that Spy1A expression is regulated downstream of c-Myc signaling. Importantly, we show that overexpression of Spy1A accelerates tumorigenesis in vivo. Collectively, this work is the first report that the Spy1/RINGO family of proteins may play an essential role in regulating both normal and abnormal growth processes in the breast.

AB - Spy1A is a unique cell cycle activator known to mediate cell cycle progression and override the DNA damage response. This study focused on determining the role of this protein on postnatal mammary gland morphogenesis and neoplasia. Herein, we show that Spy1A levels are tightly regulated during mammary gland development and that ectopic expression stimulates precocious development and results in disrupted morphology of the gland. This follows the same trend as the oncogene c-Myc, and we show that Spy1A expression is regulated downstream of c-Myc signaling. Importantly, we show that overexpression of Spy1A accelerates tumorigenesis in vivo. Collectively, this work is the first report that the Spy1/RINGO family of proteins may play an essential role in regulating both normal and abnormal growth processes in the breast.

UR - http://www.scopus.com/inward/record.url?scp=45549109869&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=45549109869&partnerID=8YFLogxK

U2 - 10.1158/0008-5472.CAN-07-6453

DO - 10.1158/0008-5472.CAN-07-6453

M3 - Article

VL - 68

SP - 3591

EP - 3600

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0099-7013

IS - 10

ER -