The stability of metabolic syndrome in children and adolescents

Jennifer K. Gustafson, Lisa B. Yanoff, Benjamin D. Easter, Sheila M. Brady, Margaret F. Keil, Mary D. Roberts, Nancy G. Sebring, Joan Han, Susan Z. Yanovski, S. Van Hubbard, Jack A. Yanovski

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Context: Some studies suggest the presence of metabolic syndrome before adulthoodmayidentify those at high risk for later cardiovascular morbidity, but there arefewdata examining the reliability of pediatric metabolic syndrome. Objective: To examine the short- and long-term stability of pediatric metabolic syndrome. Design: Metabolic syndrome was defined as having at least three of the following: waist circumference, blood pressure, and fasting serum triglycerides in the 90th or higher percentile for age/sex; high-density lipoprotein- cholesterol 10th or lower percentile for age/sex; and fasting serum glucose of at least 100 mg/dl. Short-term metabolic syndrome stability (repeated measurements within 60 d) was assessedinobeseyouthages6-17yr.Long- termmetabolicsyndromestability(repeatedmeasurements more than 1.5 yr apart) was studied in 146 obese and nonobese children age 6-12 yr at baseline. Patients and Setting: Convenience samples of obese and nonobese youth ages 6-17 yr participating in research studies were collected at a clinical research hospital. Results: Short-term metabolic syndrome stability (repeat measurements performed 19.7 ± 13.1 d apart) was assessed in 220 children. The diagnosis of metabolic syndrome was unstable in 31.6% of cases. At their short-term follow-up visit, incidence of metabolic syndrome among participants whodid not have metabolic syndrome at baselinewas24%.In the long term (repeat measurements performed 5.6±1.9 yr apart), the diagnosis of metabolic syndrome was unstable in 45.5% of cases. Conclusions: Cutoff-point-based definitions for pediatric metabolic syndrome have substantial instability in the short and long term. The value of making a cutoff-point-based diagnosis of metabolic syndrome during childhood or adolescence remains in question.

Original languageEnglish (US)
Pages (from-to)4828-4834
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume94
Issue number12
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

Fingerprint

Pediatrics
Blood pressure
HDL Cholesterol
Triglycerides
Glucose
Fasting
Waist Circumference
Serum
Research
Blood Pressure
Morbidity
Incidence

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Gustafson, J. K., Yanoff, L. B., Easter, B. D., Brady, S. M., Keil, M. F., Roberts, M. D., ... Yanovski, J. A. (2009). The stability of metabolic syndrome in children and adolescents. Journal of Clinical Endocrinology and Metabolism, 94(12), 4828-4834. https://doi.org/10.1210/jc.2008-2665

The stability of metabolic syndrome in children and adolescents. / Gustafson, Jennifer K.; Yanoff, Lisa B.; Easter, Benjamin D.; Brady, Sheila M.; Keil, Margaret F.; Roberts, Mary D.; Sebring, Nancy G.; Han, Joan; Yanovski, Susan Z.; Van Hubbard, S.; Yanovski, Jack A.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 94, No. 12, 01.01.2009, p. 4828-4834.

Research output: Contribution to journalArticle

Gustafson, JK, Yanoff, LB, Easter, BD, Brady, SM, Keil, MF, Roberts, MD, Sebring, NG, Han, J, Yanovski, SZ, Van Hubbard, S & Yanovski, JA 2009, 'The stability of metabolic syndrome in children and adolescents', Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 12, pp. 4828-4834. https://doi.org/10.1210/jc.2008-2665
Gustafson JK, Yanoff LB, Easter BD, Brady SM, Keil MF, Roberts MD et al. The stability of metabolic syndrome in children and adolescents. Journal of Clinical Endocrinology and Metabolism. 2009 Jan 1;94(12):4828-4834. https://doi.org/10.1210/jc.2008-2665
Gustafson, Jennifer K. ; Yanoff, Lisa B. ; Easter, Benjamin D. ; Brady, Sheila M. ; Keil, Margaret F. ; Roberts, Mary D. ; Sebring, Nancy G. ; Han, Joan ; Yanovski, Susan Z. ; Van Hubbard, S. ; Yanovski, Jack A. / The stability of metabolic syndrome in children and adolescents. In: Journal of Clinical Endocrinology and Metabolism. 2009 ; Vol. 94, No. 12. pp. 4828-4834.
@article{8ee8a2a9f21e49da8904cf1cd6626062,
title = "The stability of metabolic syndrome in children and adolescents",
abstract = "Context: Some studies suggest the presence of metabolic syndrome before adulthoodmayidentify those at high risk for later cardiovascular morbidity, but there arefewdata examining the reliability of pediatric metabolic syndrome. Objective: To examine the short- and long-term stability of pediatric metabolic syndrome. Design: Metabolic syndrome was defined as having at least three of the following: waist circumference, blood pressure, and fasting serum triglycerides in the 90th or higher percentile for age/sex; high-density lipoprotein- cholesterol 10th or lower percentile for age/sex; and fasting serum glucose of at least 100 mg/dl. Short-term metabolic syndrome stability (repeated measurements within 60 d) was assessedinobeseyouthages6-17yr.Long- termmetabolicsyndromestability(repeatedmeasurements more than 1.5 yr apart) was studied in 146 obese and nonobese children age 6-12 yr at baseline. Patients and Setting: Convenience samples of obese and nonobese youth ages 6-17 yr participating in research studies were collected at a clinical research hospital. Results: Short-term metabolic syndrome stability (repeat measurements performed 19.7 ± 13.1 d apart) was assessed in 220 children. The diagnosis of metabolic syndrome was unstable in 31.6{\%} of cases. At their short-term follow-up visit, incidence of metabolic syndrome among participants whodid not have metabolic syndrome at baselinewas24{\%}.In the long term (repeat measurements performed 5.6±1.9 yr apart), the diagnosis of metabolic syndrome was unstable in 45.5{\%} of cases. Conclusions: Cutoff-point-based definitions for pediatric metabolic syndrome have substantial instability in the short and long term. The value of making a cutoff-point-based diagnosis of metabolic syndrome during childhood or adolescence remains in question.",
author = "Gustafson, {Jennifer K.} and Yanoff, {Lisa B.} and Easter, {Benjamin D.} and Brady, {Sheila M.} and Keil, {Margaret F.} and Roberts, {Mary D.} and Sebring, {Nancy G.} and Joan Han and Yanovski, {Susan Z.} and {Van Hubbard}, S. and Yanovski, {Jack A.}",
year = "2009",
month = "1",
day = "1",
doi = "10.1210/jc.2008-2665",
language = "English (US)",
volume = "94",
pages = "4828--4834",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "12",

}

TY - JOUR

T1 - The stability of metabolic syndrome in children and adolescents

AU - Gustafson, Jennifer K.

AU - Yanoff, Lisa B.

AU - Easter, Benjamin D.

AU - Brady, Sheila M.

AU - Keil, Margaret F.

AU - Roberts, Mary D.

AU - Sebring, Nancy G.

AU - Han, Joan

AU - Yanovski, Susan Z.

AU - Van Hubbard, S.

AU - Yanovski, Jack A.

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Context: Some studies suggest the presence of metabolic syndrome before adulthoodmayidentify those at high risk for later cardiovascular morbidity, but there arefewdata examining the reliability of pediatric metabolic syndrome. Objective: To examine the short- and long-term stability of pediatric metabolic syndrome. Design: Metabolic syndrome was defined as having at least three of the following: waist circumference, blood pressure, and fasting serum triglycerides in the 90th or higher percentile for age/sex; high-density lipoprotein- cholesterol 10th or lower percentile for age/sex; and fasting serum glucose of at least 100 mg/dl. Short-term metabolic syndrome stability (repeated measurements within 60 d) was assessedinobeseyouthages6-17yr.Long- termmetabolicsyndromestability(repeatedmeasurements more than 1.5 yr apart) was studied in 146 obese and nonobese children age 6-12 yr at baseline. Patients and Setting: Convenience samples of obese and nonobese youth ages 6-17 yr participating in research studies were collected at a clinical research hospital. Results: Short-term metabolic syndrome stability (repeat measurements performed 19.7 ± 13.1 d apart) was assessed in 220 children. The diagnosis of metabolic syndrome was unstable in 31.6% of cases. At their short-term follow-up visit, incidence of metabolic syndrome among participants whodid not have metabolic syndrome at baselinewas24%.In the long term (repeat measurements performed 5.6±1.9 yr apart), the diagnosis of metabolic syndrome was unstable in 45.5% of cases. Conclusions: Cutoff-point-based definitions for pediatric metabolic syndrome have substantial instability in the short and long term. The value of making a cutoff-point-based diagnosis of metabolic syndrome during childhood or adolescence remains in question.

AB - Context: Some studies suggest the presence of metabolic syndrome before adulthoodmayidentify those at high risk for later cardiovascular morbidity, but there arefewdata examining the reliability of pediatric metabolic syndrome. Objective: To examine the short- and long-term stability of pediatric metabolic syndrome. Design: Metabolic syndrome was defined as having at least three of the following: waist circumference, blood pressure, and fasting serum triglycerides in the 90th or higher percentile for age/sex; high-density lipoprotein- cholesterol 10th or lower percentile for age/sex; and fasting serum glucose of at least 100 mg/dl. Short-term metabolic syndrome stability (repeated measurements within 60 d) was assessedinobeseyouthages6-17yr.Long- termmetabolicsyndromestability(repeatedmeasurements more than 1.5 yr apart) was studied in 146 obese and nonobese children age 6-12 yr at baseline. Patients and Setting: Convenience samples of obese and nonobese youth ages 6-17 yr participating in research studies were collected at a clinical research hospital. Results: Short-term metabolic syndrome stability (repeat measurements performed 19.7 ± 13.1 d apart) was assessed in 220 children. The diagnosis of metabolic syndrome was unstable in 31.6% of cases. At their short-term follow-up visit, incidence of metabolic syndrome among participants whodid not have metabolic syndrome at baselinewas24%.In the long term (repeat measurements performed 5.6±1.9 yr apart), the diagnosis of metabolic syndrome was unstable in 45.5% of cases. Conclusions: Cutoff-point-based definitions for pediatric metabolic syndrome have substantial instability in the short and long term. The value of making a cutoff-point-based diagnosis of metabolic syndrome during childhood or adolescence remains in question.

UR - http://www.scopus.com/inward/record.url?scp=73249137392&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73249137392&partnerID=8YFLogxK

U2 - 10.1210/jc.2008-2665

DO - 10.1210/jc.2008-2665

M3 - Article

VL - 94

SP - 4828

EP - 4834

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 12

ER -