The structure and function of serum opacity factor: A unique streptococcal virulence determinant that targets high-density lipoproteins

Harry Courtney, Henry J. Pownall

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Serum opacity factor (SOF) is a virulence determinant expressed by a variety of streptococcal and staphylococcal species including both human and animal pathogens. SOF derives its name from its ability to opacify serum where it targets and disrupts the structure of high-density lipoproteins resulting in formation of large lipid vesicles that cause the serum to become cloudy. SOF is a multifunctional protein and in addition to its opacification activity, it binds to a number of host proteins that mediate adhesion of streptococci to host cells, and it plays a role in resistance to phagocytosis in human blood. This article will provide an overview of the structure and function of SOF, its role in the pathogenesis of streptococcal infections, its vaccine potential, its prevalence and distribution in bacteria, and the molecular mechanism whereby SOF opacifies serum and how an understanding of this mechanism may lead to therapies for reducing high-cholesterol concentrations in blood, a major risk factor for cardiovascular disease.

Original languageEnglish (US)
Article number956071
JournalJournal of Biomedicine and Biotechnology
Volume2010
DOIs
StatePublished - Aug 13 2010

Fingerprint

HDL Lipoproteins
Virulence
Blood
Serum
Streptococcal Infections
Pathogens
Streptococcus
Phagocytosis
Names
Bacteria
Animals
Proteins
Cardiovascular Diseases
Adhesion
Vaccines
Cholesterol
opacity factor
Lipids

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Medicine(all)
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

Cite this

The structure and function of serum opacity factor : A unique streptococcal virulence determinant that targets high-density lipoproteins. / Courtney, Harry; Pownall, Henry J.

In: Journal of Biomedicine and Biotechnology, Vol. 2010, 956071, 13.08.2010.

Research output: Contribution to journalReview article

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