The subthalamic nucleus is one of multiple innervation sites for long-range corticofugal axons

A single-axon tracing study in the rat

Takako Kita, Hitoshi Kita

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

The frontal cortex provides strong excitatory inputs to the subthalamic nucleus (STN), and these cortico-STN inputs play critical roles in the control of basal ganglia activity. It has been assumed from anatomical and physiological studies that STN is innervated mainly by collaterals of thick and fast conducting pyramidal tract axons originating from the frontal cortex deep layerVneurons, implying that STN directly receives efferent copies of motor commands. To more closely examine this assumption, we performed biotinylated dextran amine anterograde tracing studies in rats to examine the cortical layer of origin, the sizes of parent axons, and whether or not the cortical axons emit any other collaterals to brain areas other than STN. This study revealed that the cortico-STN projection is formed mostly by collaterals of a small fraction of small-to-medium-sized long-range corticofugal axons, which also emit collaterals that innervate multiple other brain sites including the striatum, associative thalamic nuclei, superior colliculus, zona incerta, pontine nucleus, multiple other brainstem areas, and the spinal cord. The results imply that some layer V neurons are involved in associative control of movement through multiple brain innervation sites and that the cortico-STN projection is one part of this multiple corticofugal system.

Original languageEnglish (US)
Pages (from-to)5990-5999
Number of pages10
JournalJournal of Neuroscience
Volume32
Issue number17
DOIs
StatePublished - Apr 25 2012

Fingerprint

Subthalamic Nucleus
Axons
Frontal Lobe
Brain
Thalamic Nuclei
Pyramidal Tracts
Superior Colliculi
Basal Ganglia
Brain Stem
Spinal Cord
Neurons

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

The subthalamic nucleus is one of multiple innervation sites for long-range corticofugal axons : A single-axon tracing study in the rat. / Kita, Takako; Kita, Hitoshi.

In: Journal of Neuroscience, Vol. 32, No. 17, 25.04.2012, p. 5990-5999.

Research output: Contribution to journalArticle

@article{c52af149dfaf45daa8a91c647464fef6,
title = "The subthalamic nucleus is one of multiple innervation sites for long-range corticofugal axons: A single-axon tracing study in the rat",
abstract = "The frontal cortex provides strong excitatory inputs to the subthalamic nucleus (STN), and these cortico-STN inputs play critical roles in the control of basal ganglia activity. It has been assumed from anatomical and physiological studies that STN is innervated mainly by collaterals of thick and fast conducting pyramidal tract axons originating from the frontal cortex deep layerVneurons, implying that STN directly receives efferent copies of motor commands. To more closely examine this assumption, we performed biotinylated dextran amine anterograde tracing studies in rats to examine the cortical layer of origin, the sizes of parent axons, and whether or not the cortical axons emit any other collaterals to brain areas other than STN. This study revealed that the cortico-STN projection is formed mostly by collaterals of a small fraction of small-to-medium-sized long-range corticofugal axons, which also emit collaterals that innervate multiple other brain sites including the striatum, associative thalamic nuclei, superior colliculus, zona incerta, pontine nucleus, multiple other brainstem areas, and the spinal cord. The results imply that some layer V neurons are involved in associative control of movement through multiple brain innervation sites and that the cortico-STN projection is one part of this multiple corticofugal system.",
author = "Takako Kita and Hitoshi Kita",
year = "2012",
month = "4",
day = "25",
doi = "10.1523/JNEUROSCI.5717-11.2012",
language = "English (US)",
volume = "32",
pages = "5990--5999",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "17",

}

TY - JOUR

T1 - The subthalamic nucleus is one of multiple innervation sites for long-range corticofugal axons

T2 - A single-axon tracing study in the rat

AU - Kita, Takako

AU - Kita, Hitoshi

PY - 2012/4/25

Y1 - 2012/4/25

N2 - The frontal cortex provides strong excitatory inputs to the subthalamic nucleus (STN), and these cortico-STN inputs play critical roles in the control of basal ganglia activity. It has been assumed from anatomical and physiological studies that STN is innervated mainly by collaterals of thick and fast conducting pyramidal tract axons originating from the frontal cortex deep layerVneurons, implying that STN directly receives efferent copies of motor commands. To more closely examine this assumption, we performed biotinylated dextran amine anterograde tracing studies in rats to examine the cortical layer of origin, the sizes of parent axons, and whether or not the cortical axons emit any other collaterals to brain areas other than STN. This study revealed that the cortico-STN projection is formed mostly by collaterals of a small fraction of small-to-medium-sized long-range corticofugal axons, which also emit collaterals that innervate multiple other brain sites including the striatum, associative thalamic nuclei, superior colliculus, zona incerta, pontine nucleus, multiple other brainstem areas, and the spinal cord. The results imply that some layer V neurons are involved in associative control of movement through multiple brain innervation sites and that the cortico-STN projection is one part of this multiple corticofugal system.

AB - The frontal cortex provides strong excitatory inputs to the subthalamic nucleus (STN), and these cortico-STN inputs play critical roles in the control of basal ganglia activity. It has been assumed from anatomical and physiological studies that STN is innervated mainly by collaterals of thick and fast conducting pyramidal tract axons originating from the frontal cortex deep layerVneurons, implying that STN directly receives efferent copies of motor commands. To more closely examine this assumption, we performed biotinylated dextran amine anterograde tracing studies in rats to examine the cortical layer of origin, the sizes of parent axons, and whether or not the cortical axons emit any other collaterals to brain areas other than STN. This study revealed that the cortico-STN projection is formed mostly by collaterals of a small fraction of small-to-medium-sized long-range corticofugal axons, which also emit collaterals that innervate multiple other brain sites including the striatum, associative thalamic nuclei, superior colliculus, zona incerta, pontine nucleus, multiple other brainstem areas, and the spinal cord. The results imply that some layer V neurons are involved in associative control of movement through multiple brain innervation sites and that the cortico-STN projection is one part of this multiple corticofugal system.

UR - http://www.scopus.com/inward/record.url?scp=84860156184&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860156184&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.5717-11.2012

DO - 10.1523/JNEUROSCI.5717-11.2012

M3 - Article

VL - 32

SP - 5990

EP - 5999

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 17

ER -