The synthesis and use of boronated amino acids for boron neutron capture therapy

George Kabalka, Min Liang Yao

Research output: Contribution to journalReview article

44 Citations (Scopus)

Abstract

The treatment of cancer remains one of the most challenging problems for humanity. Boron neutron capture therapy (BNCT) is a binary approach for cancer treatment that is particularly attractive in treating high-grade gliomas and metastatic brain tumors. Among types of boron-containing molecules used as BNCT agents, boronated amino acids have received significant attention for their preferentially uptake by growing tumor cells. This review emphasizes the synthesis of boronated amino acids.

Original languageEnglish (US)
Pages (from-to)111-125
Number of pages15
JournalAnti-Cancer Agents in Medicinal Chemistry
Volume6
Issue number2
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

Fingerprint

Boron Neutron Capture Therapy
Amino Acids
Neoplasms
Boron
Brain Neoplasms
Glioma
Therapeutics

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Cancer Research

Cite this

The synthesis and use of boronated amino acids for boron neutron capture therapy. / Kabalka, George; Yao, Min Liang.

In: Anti-Cancer Agents in Medicinal Chemistry, Vol. 6, No. 2, 01.03.2006, p. 111-125.

Research output: Contribution to journalReview article

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