The taurine transporter gene and its role in renal development

Xiaobin Han, A. M. Budreau, R. W. Chesney

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

This paper examines a unique hypothesis regarding an important role for taurine in renal development. Taurine-deficient neonatal kittens show renal developmental abnormalities, one of several lines of support for this speculation. Adaptive regulation of the taurine transporter gene is critical in mammalian species because maintenance of adequate tissue levels of taurine is essential to the normal development of the retina and the central nervous system. Observations of the remarkable phenotypic similarity that exists between children with deletion of bands p25-pter of chromosome 3 and taurine-deficient kits led us to hypothesize that deletion of the renal taurine transporter gene (TauT) might contribute to some features of the 3p-syndrome. Further, the renal taurine transporter gene is down-regulated by the tumor suppressor gene p53, and up-regulated by the Wilms tumor (WT-1) and early growth response-1 (EGR-1) genes. It has been demonstrated using WT-1 gene knockout mice that WT-1 is critical for normal renal development. In contrast, transgenic mice overexpressing the p53 gene have renal development defects, including hypoplasia similar to that observed in the taurine-deficient kitten. This paper reviews evidence that altered expression of the renal taurine transporter may result in reduced intracellular taurine content, which in turn may lead to abnormal cell volume regulation, cell death and, ultimately, defective renal development.

Original languageEnglish (US)
Pages (from-to)499-507
Number of pages9
JournalAmino Acids
Volume19
Issue number3-4
DOIs
StatePublished - Jan 1 2000

Fingerprint

Taurine
Genes
Kidney
Tumors
Neurology
Gene Knockout Techniques
Cell death
Chromosomes, Human, Pair 3
Chromosomes
Wilms Tumor
taurine transporter
p53 Genes
Tumor Suppressor Genes
Cell Size
Knockout Mice
Transgenic Mice
Retina
Cell Death
Tissue
Central Nervous System

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

The taurine transporter gene and its role in renal development. / Han, Xiaobin; Budreau, A. M.; Chesney, R. W.

In: Amino Acids, Vol. 19, No. 3-4, 01.01.2000, p. 499-507.

Research output: Contribution to journalArticle

Han, Xiaobin ; Budreau, A. M. ; Chesney, R. W. / The taurine transporter gene and its role in renal development. In: Amino Acids. 2000 ; Vol. 19, No. 3-4. pp. 499-507.
@article{4fcb428ad1c44b22b63848f406abef4d,
title = "The taurine transporter gene and its role in renal development",
abstract = "This paper examines a unique hypothesis regarding an important role for taurine in renal development. Taurine-deficient neonatal kittens show renal developmental abnormalities, one of several lines of support for this speculation. Adaptive regulation of the taurine transporter gene is critical in mammalian species because maintenance of adequate tissue levels of taurine is essential to the normal development of the retina and the central nervous system. Observations of the remarkable phenotypic similarity that exists between children with deletion of bands p25-pter of chromosome 3 and taurine-deficient kits led us to hypothesize that deletion of the renal taurine transporter gene (TauT) might contribute to some features of the 3p-syndrome. Further, the renal taurine transporter gene is down-regulated by the tumor suppressor gene p53, and up-regulated by the Wilms tumor (WT-1) and early growth response-1 (EGR-1) genes. It has been demonstrated using WT-1 gene knockout mice that WT-1 is critical for normal renal development. In contrast, transgenic mice overexpressing the p53 gene have renal development defects, including hypoplasia similar to that observed in the taurine-deficient kitten. This paper reviews evidence that altered expression of the renal taurine transporter may result in reduced intracellular taurine content, which in turn may lead to abnormal cell volume regulation, cell death and, ultimately, defective renal development.",
author = "Xiaobin Han and Budreau, {A. M.} and Chesney, {R. W.}",
year = "2000",
month = "1",
day = "1",
doi = "10.1007/s007260070002",
language = "English (US)",
volume = "19",
pages = "499--507",
journal = "Amino Acids",
issn = "0939-4451",
publisher = "Springer Wien",
number = "3-4",

}

TY - JOUR

T1 - The taurine transporter gene and its role in renal development

AU - Han, Xiaobin

AU - Budreau, A. M.

AU - Chesney, R. W.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - This paper examines a unique hypothesis regarding an important role for taurine in renal development. Taurine-deficient neonatal kittens show renal developmental abnormalities, one of several lines of support for this speculation. Adaptive regulation of the taurine transporter gene is critical in mammalian species because maintenance of adequate tissue levels of taurine is essential to the normal development of the retina and the central nervous system. Observations of the remarkable phenotypic similarity that exists between children with deletion of bands p25-pter of chromosome 3 and taurine-deficient kits led us to hypothesize that deletion of the renal taurine transporter gene (TauT) might contribute to some features of the 3p-syndrome. Further, the renal taurine transporter gene is down-regulated by the tumor suppressor gene p53, and up-regulated by the Wilms tumor (WT-1) and early growth response-1 (EGR-1) genes. It has been demonstrated using WT-1 gene knockout mice that WT-1 is critical for normal renal development. In contrast, transgenic mice overexpressing the p53 gene have renal development defects, including hypoplasia similar to that observed in the taurine-deficient kitten. This paper reviews evidence that altered expression of the renal taurine transporter may result in reduced intracellular taurine content, which in turn may lead to abnormal cell volume regulation, cell death and, ultimately, defective renal development.

AB - This paper examines a unique hypothesis regarding an important role for taurine in renal development. Taurine-deficient neonatal kittens show renal developmental abnormalities, one of several lines of support for this speculation. Adaptive regulation of the taurine transporter gene is critical in mammalian species because maintenance of adequate tissue levels of taurine is essential to the normal development of the retina and the central nervous system. Observations of the remarkable phenotypic similarity that exists between children with deletion of bands p25-pter of chromosome 3 and taurine-deficient kits led us to hypothesize that deletion of the renal taurine transporter gene (TauT) might contribute to some features of the 3p-syndrome. Further, the renal taurine transporter gene is down-regulated by the tumor suppressor gene p53, and up-regulated by the Wilms tumor (WT-1) and early growth response-1 (EGR-1) genes. It has been demonstrated using WT-1 gene knockout mice that WT-1 is critical for normal renal development. In contrast, transgenic mice overexpressing the p53 gene have renal development defects, including hypoplasia similar to that observed in the taurine-deficient kitten. This paper reviews evidence that altered expression of the renal taurine transporter may result in reduced intracellular taurine content, which in turn may lead to abnormal cell volume regulation, cell death and, ultimately, defective renal development.

UR - http://www.scopus.com/inward/record.url?scp=0033662483&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033662483&partnerID=8YFLogxK

U2 - 10.1007/s007260070002

DO - 10.1007/s007260070002

M3 - Article

VL - 19

SP - 499

EP - 507

JO - Amino Acids

JF - Amino Acids

SN - 0939-4451

IS - 3-4

ER -