The total synthesis of eupomatilones 2 and 5

George Kabalka, Bollu Venkataiah

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Efficient and diastereocontrolled syntheses of natural lignans eupomatilone 2 (1) and 5 (2) are described. Biaryl coupling was achieved using Suzuki chemistry. The lactone moiety was constructed using allylmetal reagents, which were synthesized from Baylis-Hillman adducts. Allylindium reagents were found to be most effective.

Original languageEnglish (US)
Pages (from-to)7325-7328
Number of pages4
JournalTetrahedron Letters
Volume46
Issue number43
DOIs
StatePublished - Oct 24 2005
Externally publishedYes

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Lignans
Lactones
eupomatilone-2
eupomatilone-5
eupomatilone-1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

The total synthesis of eupomatilones 2 and 5. / Kabalka, George; Venkataiah, Bollu.

In: Tetrahedron Letters, Vol. 46, No. 43, 24.10.2005, p. 7325-7328.

Research output: Contribution to journalArticle

Kabalka, George ; Venkataiah, Bollu. / The total synthesis of eupomatilones 2 and 5. In: Tetrahedron Letters. 2005 ; Vol. 46, No. 43. pp. 7325-7328.
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