The treatment of gastric ulcer with antisecretory drugs - Relationship of pharmacological effect to healing rates

Colin Howden, D. B. Jones, K. E. Peace, D. W. Burget, R. H. Hunt

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Published clinical trials (N=56) of antisecretory drugs in the treatment of benign gastric ulcer were reviewed. Composite healing rates for various drug regimens were calculated using a method previously described for duodenal ulcer. Healing rates were compared with data on suppression of intragastric acidity to see if any relationship was evident. No significant correlations between the two existed, unless placebo data were included in the analysis. Correlations were stronger with suppression of total 24-hr rather than nocturnal acidity. Using Williams' method for assessing trends, it was found that an increase in antisecretory effect is not associated with a concomitant increase in healing rates. Duration of medical treatment is the single most important factor in healing of benign gastric ulcer; healing rates for all drug regimens and placebo show a consistent increase with prolongation of treatment.

Original languageEnglish (US)
Pages (from-to)619-624
Number of pages6
JournalDigestive Diseases and Sciences
Volume33
Issue number5
DOIs
StatePublished - May 1 1988
Externally publishedYes

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Stomach Ulcer
Pharmacology
Placebos
Pharmaceutical Preparations
Duodenal Ulcer
Therapeutics
Clinical Trials

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

The treatment of gastric ulcer with antisecretory drugs - Relationship of pharmacological effect to healing rates. / Howden, Colin; Jones, D. B.; Peace, K. E.; Burget, D. W.; Hunt, R. H.

In: Digestive Diseases and Sciences, Vol. 33, No. 5, 01.05.1988, p. 619-624.

Research output: Contribution to journalArticle

Howden, Colin ; Jones, D. B. ; Peace, K. E. ; Burget, D. W. ; Hunt, R. H. / The treatment of gastric ulcer with antisecretory drugs - Relationship of pharmacological effect to healing rates. In: Digestive Diseases and Sciences. 1988 ; Vol. 33, No. 5. pp. 619-624.
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