The truth about mouse, human, worms and yeast.

David Nelson, Daniel W. Nebert

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Genome comparisons are behind the powerful new annotation methods being developed to find all human genes, as well as genes from other genomes. Genomes are now frequently being studied in pairs to provide cross-comparison datasets. This 'Noah's Ark' approach often reveals unsuspected genes and may support the deletion of false-positive predictions. Joining mouse and human as the cross-comparison dataset for the first two mammals are: two Drosophila species, D. melanogaster and D. pseudoobscura; two sea squirts, Ciona intestinalis and Ciona savignyi; four yeast (Saccharomyces) species; two nematodes, Caenorhabditis elegans and Caenorhabditis briggsae; and two pufferfish (Takefugu rubripes and Tetraodon nigroviridis). Even genomes like yeast and C. elegans, which have been known for more than five years, are now being significantly improved. Methods developed for yeast or nematodes will now be applied to mouse and human, and soon to additional mammals such as rat and dog, to identify all the mammalian protein-coding genes. Current large disparities between human Unigene predictions (127,835 genes) and gene-scanning methods (45,000 genes) still need to be resolved. This will be the challenge during the next few years.

Original languageEnglish (US)
Pages (from-to)146-149
Number of pages4
JournalHuman Genomics
Volume1
Issue number2
StatePublished - Jan 1 2004

Fingerprint

Yeasts
Genome
Genes
Caenorhabditis elegans
Mammals
Caenorhabditis
Ciona intestinalis
Tetraodontiformes
Saccharomyces
Oceans and Seas
Drosophila
Dogs
Proteins
Datasets

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Drug Discovery

Cite this

The truth about mouse, human, worms and yeast. / Nelson, David; Nebert, Daniel W.

In: Human Genomics, Vol. 1, No. 2, 01.01.2004, p. 146-149.

Research output: Contribution to journalArticle

Nelson, D & Nebert, DW 2004, 'The truth about mouse, human, worms and yeast.', Human Genomics, vol. 1, no. 2, pp. 146-149.
Nelson, David ; Nebert, Daniel W. / The truth about mouse, human, worms and yeast. In: Human Genomics. 2004 ; Vol. 1, No. 2. pp. 146-149.
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