The use of 5-aminolevulinic acid in resection of pediatric brain tumors

a critical review

Chenran Zhang, Frederick Boop, John Ruge

Research output: Contribution to journalReview article

Abstract

The compound, 5-aminolevulinic acid (5-ALA) is approved for fluorescence-guided resections of malignant gliomas in Europe and other countries for use in adults, but not for children. The application of 5-ALA in children remains an off-label use. Several case reports on fluorescence-guided surgery use in children have been published, yet no prospective study has been conducted. Here we systematically review the reported studies and discuss the usefulness, application, and safety of 5-ALA use in resection of pediatric brain tumors.

Original languageEnglish (US)
Pages (from-to)567-573
Number of pages7
JournalJournal of Neuro-Oncology
Volume141
Issue number3
DOIs
StatePublished - Feb 15 2019

Fingerprint

Aminolevulinic Acid
Brain Neoplasms
Pediatrics
Fluorescence
Off-Label Use
Glioma
Prospective Studies
Safety

All Science Journal Classification (ASJC) codes

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

Cite this

The use of 5-aminolevulinic acid in resection of pediatric brain tumors : a critical review. / Zhang, Chenran; Boop, Frederick; Ruge, John.

In: Journal of Neuro-Oncology, Vol. 141, No. 3, 15.02.2019, p. 567-573.

Research output: Contribution to journalReview article

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