The use of adjuvant radiation therapy in patients with intermediate-risk Stages IC and II uterine corpus cancer

A patient care evaluation study from the American College of Surgeons National Cancer Data Base

J. Michael Straughn, T. Michael Numnum, Larry Kilgore, Edward E. Partridge, Jerri Linn Phillips, Maurie Markman, Gillian M. Thomas, Thomas W. Burke

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective. To determine the outcomes of patients with intermediate-risk Stages IC and II uterine corpus cancer treated with surgery alone or surgery followed by radiation therapy. Methods. Patients with uterine corpus cancer diagnosed in 1995 were identified from hospitals in the United States with tumor registry databases. Data were collected on histology, surgical treatment, radiation therapy, recurrence, and survival. Survival analysis was performed using life-table computational method. Results. 713 hospitals submitted data on 10,726 patients with uterine corpus cancer. 9977 patients (93.0%) underwent surgery, and 2624 patients (26.3%) received radiation therapy. Patients with clinical Stages IC and IIA disease who underwent surgery followed by radiation therapy compared to surgery alone had a trend toward improved 5-year relative survival (RS) (81.2% vs. 92.5%; 74.3% vs. 96.0%, respectively). The 5-year RS of patients with surgical Stage IC disease was not statistically different between the surgery alone group and the radiation group (93.9% vs. 91.7%). Patients with surgical Stage IIA and IIB disease did not benefit from radiation therapy compared to surgery alone (5-year RS; 83.7% vs. 98.0% and 82.3% vs. 81.8%, respectively). Conclusion. There is a trend toward improved survival in patients with clinical Stages IC and IIA uterine corpus cancer when radiation therapy is utilized following surgery. The survival of patients with surgical Stages IC and II uterine corpus cancer is not improved with adjuvant radiation therapy.

Original languageEnglish (US)
Pages (from-to)530-535
Number of pages6
JournalGynecologic oncology
Volume99
Issue number3
DOIs
StatePublished - Dec 1 2005

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Uterine Neoplasms
Patient Care
Radiotherapy
Databases
Neoplasms
Survival
Life Tables
Survival Analysis
Registries
Histology
Radiation
Recurrence

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynecology

Cite this

The use of adjuvant radiation therapy in patients with intermediate-risk Stages IC and II uterine corpus cancer : A patient care evaluation study from the American College of Surgeons National Cancer Data Base. / Straughn, J. Michael; Numnum, T. Michael; Kilgore, Larry; Partridge, Edward E.; Phillips, Jerri Linn; Markman, Maurie; Thomas, Gillian M.; Burke, Thomas W.

In: Gynecologic oncology, Vol. 99, No. 3, 01.12.2005, p. 530-535.

Research output: Contribution to journalArticle

Straughn, J. Michael ; Numnum, T. Michael ; Kilgore, Larry ; Partridge, Edward E. ; Phillips, Jerri Linn ; Markman, Maurie ; Thomas, Gillian M. ; Burke, Thomas W. / The use of adjuvant radiation therapy in patients with intermediate-risk Stages IC and II uterine corpus cancer : A patient care evaluation study from the American College of Surgeons National Cancer Data Base. In: Gynecologic oncology. 2005 ; Vol. 99, No. 3. pp. 530-535.
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abstract = "Objective. To determine the outcomes of patients with intermediate-risk Stages IC and II uterine corpus cancer treated with surgery alone or surgery followed by radiation therapy. Methods. Patients with uterine corpus cancer diagnosed in 1995 were identified from hospitals in the United States with tumor registry databases. Data were collected on histology, surgical treatment, radiation therapy, recurrence, and survival. Survival analysis was performed using life-table computational method. Results. 713 hospitals submitted data on 10,726 patients with uterine corpus cancer. 9977 patients (93.0{\%}) underwent surgery, and 2624 patients (26.3{\%}) received radiation therapy. Patients with clinical Stages IC and IIA disease who underwent surgery followed by radiation therapy compared to surgery alone had a trend toward improved 5-year relative survival (RS) (81.2{\%} vs. 92.5{\%}; 74.3{\%} vs. 96.0{\%}, respectively). The 5-year RS of patients with surgical Stage IC disease was not statistically different between the surgery alone group and the radiation group (93.9{\%} vs. 91.7{\%}). Patients with surgical Stage IIA and IIB disease did not benefit from radiation therapy compared to surgery alone (5-year RS; 83.7{\%} vs. 98.0{\%} and 82.3{\%} vs. 81.8{\%}, respectively). Conclusion. There is a trend toward improved survival in patients with clinical Stages IC and IIA uterine corpus cancer when radiation therapy is utilized following surgery. The survival of patients with surgical Stages IC and II uterine corpus cancer is not improved with adjuvant radiation therapy.",
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N2 - Objective. To determine the outcomes of patients with intermediate-risk Stages IC and II uterine corpus cancer treated with surgery alone or surgery followed by radiation therapy. Methods. Patients with uterine corpus cancer diagnosed in 1995 were identified from hospitals in the United States with tumor registry databases. Data were collected on histology, surgical treatment, radiation therapy, recurrence, and survival. Survival analysis was performed using life-table computational method. Results. 713 hospitals submitted data on 10,726 patients with uterine corpus cancer. 9977 patients (93.0%) underwent surgery, and 2624 patients (26.3%) received radiation therapy. Patients with clinical Stages IC and IIA disease who underwent surgery followed by radiation therapy compared to surgery alone had a trend toward improved 5-year relative survival (RS) (81.2% vs. 92.5%; 74.3% vs. 96.0%, respectively). The 5-year RS of patients with surgical Stage IC disease was not statistically different between the surgery alone group and the radiation group (93.9% vs. 91.7%). Patients with surgical Stage IIA and IIB disease did not benefit from radiation therapy compared to surgery alone (5-year RS; 83.7% vs. 98.0% and 82.3% vs. 81.8%, respectively). Conclusion. There is a trend toward improved survival in patients with clinical Stages IC and IIA uterine corpus cancer when radiation therapy is utilized following surgery. The survival of patients with surgical Stages IC and II uterine corpus cancer is not improved with adjuvant radiation therapy.

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