The use of labetalol for attenuation of the hypertensive response to endotracheal incubation in preeclampsia

Jaya Ramanathan, Baha M. Sibai, William C. Mabie, Dinesh Chauhan, Antonio G. Ruiz

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Abstract

Twenty-five women with preeclampsia who were scheduled to undergo cesarean section under general anesthesia were randomly assigned to either a labetalol pretreatment group (n = 15) or a control group (n = 10) who did not receive any antihypertensive therapy before the induction of anesthesia. Patients in the labetalol group received 20 mg of labetalol intravenously followed by 10 mg increments up to a total dose of 1 mg/kg, which resulted in moderate reductions in the maternal mean arterial pressure and heart rate with attenuation of the hypertensive and tachycardiac responses to laryngoscopy and endotracheal intubation. In the labetalol group there was no excessive reduction in the mean arterial pressure with the use of isoflurane and the usual amount of blood loss that occurred during cesarean section. The neonatal Apgar scores and umbilical arterial and venous pH and blood gas values were similar in the two groups. Side effects such as hypotension, bradycardia, and hypoglycemia were not seen in the neonates in the labetalol treatment group.

Original languageEnglish (US)
Pages (from-to)650-654
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume159
Issue number3
DOIs
StatePublished - Jan 1 1988

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Labetalol
Pre-Eclampsia
Cesarean Section
Arterial Pressure
Umbilicus
Laryngoscopy
Intratracheal Intubation
Apgar Score
Isoflurane
Bradycardia
Hypoglycemia
Hypotension
General Anesthesia
Antihypertensive Agents
Anesthesia
Heart Rate
Gases
Mothers
Newborn Infant
Control Groups

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

The use of labetalol for attenuation of the hypertensive response to endotracheal incubation in preeclampsia. / Ramanathan, Jaya; Sibai, Baha M.; Mabie, William C.; Chauhan, Dinesh; Ruiz, Antonio G.

In: American Journal of Obstetrics and Gynecology, Vol. 159, No. 3, 01.01.1988, p. 650-654.

Research output: Contribution to journalArticle

Ramanathan, Jaya ; Sibai, Baha M. ; Mabie, William C. ; Chauhan, Dinesh ; Ruiz, Antonio G. / The use of labetalol for attenuation of the hypertensive response to endotracheal incubation in preeclampsia. In: American Journal of Obstetrics and Gynecology. 1988 ; Vol. 159, No. 3. pp. 650-654.
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