The utilization of quantitative trait loci in toxicogenetics.

G. E. McClearn, Byron Jones, D. A. Blizard, R. Plomin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

With the increasing number of marker loci available in mouse, the traditional method of recombinant inbred strains can be extended to searches for quantitative trait loci (QTL) influencing continuously distributed phenotypes. These loci have effect sizes too small to be easily detectable by conventional single-locus techniques. Collective, several QTL may account for a substantial proportion of the phenotypic variability. Prospective advantages of location of QTL in toxicology-relevant phenotypes include opportunities for the study of mechanism, prospects of generating animal models by genotypic selection, study of the dynamics of gene interaction, and guiding the search for homologous genes in human beings.

Original languageEnglish (US)
Pages (from-to)251-258
Number of pages8
JournalJournal of Experimental Animal Science
Volume35
Issue number5-6
StatePublished - Sep 1993
Externally publishedYes

Fingerprint

toxicogenomics
Toxicogenetics
Quantitative Trait Loci
quantitative trait loci
loci
Phenotype
phenotype
gene interaction
toxicology
Toxicology
Genes
Animal Models
animal models
mice
methodology
genes

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology
  • veterinary(all)

Cite this

McClearn, G. E., Jones, B., Blizard, D. A., & Plomin, R. (1993). The utilization of quantitative trait loci in toxicogenetics. Journal of Experimental Animal Science, 35(5-6), 251-258.

The utilization of quantitative trait loci in toxicogenetics. / McClearn, G. E.; Jones, Byron; Blizard, D. A.; Plomin, R.

In: Journal of Experimental Animal Science, Vol. 35, No. 5-6, 09.1993, p. 251-258.

Research output: Contribution to journalArticle

McClearn, GE, Jones, B, Blizard, DA & Plomin, R 1993, 'The utilization of quantitative trait loci in toxicogenetics.', Journal of Experimental Animal Science, vol. 35, no. 5-6, pp. 251-258.
McClearn, G. E. ; Jones, Byron ; Blizard, D. A. ; Plomin, R. / The utilization of quantitative trait loci in toxicogenetics. In: Journal of Experimental Animal Science. 1993 ; Vol. 35, No. 5-6. pp. 251-258.
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