The Vaccine Safety Datalink: Immunization research in health maintenance organizations in the USA

R. T. Chen, F. DeStefano, R. L. Davis, L. A. Jackson, R. S. Thompson, J. P. Mullooly, S. B. Black, H. R. Shinefield, C. M. Vadheim, J. I. Ward, S. M. Marcy, J. Glasser, P. H. Rhodes, S. Wassilak, P. Kramarz, E. Swint, D. Walker, C. Okoro, P. Gargiullo, D. BaughmanD. King, P. Benson, V. Immanuel, W. Barlow, K. Bohlke, P. L. Poy, V. Rebolledo, D. Rubanowice, L. Mell, M. Lafrance, L. Huggins, J. Dhillon, A. Zavitkovsky, A. Salazar, E. Adams, M. Shafer, M. Sunderland, J. Habanangas, J. Drake, J. Kramer, L. Drew, K. Olson, J. Mesa, J. A. Pearson, M. Allison, A. Bauck, N. Redmond, T. A. Lieu, P. Ray, E. Lewis, B. H. Fireman, H. Lee, J. Jing, N. Goff, S. M. Marcy, M. Lugg, M. M. Braun, R. P. Wise, M. E. Salive, V. Caserta

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

The Vaccine Safety Datalink is a collaborative project involving the National Immunization Program of the Centers for Disease Control and Prevention and several large health maintenance organizations in the USA. The project began in 1990 with the primary purpose of rigorously evaluating concerns about the safety of vaccines. Computerized data on vaccination, medical outcome (e.g. outpatient visits, emergency room visits, hospitalizations, and deaths) and covariates (e.g. birth certificates, census data) are prospectively collected and linked under joint protocol at multiple health maintenance organizations for analysis. Approximately 6 million persons (2% of the population of the USA) are now members of health maintenance organizations participating in the Vaccine Safety Datalink, which has proved to be a valuable resource providing important information on a number of vaccine safety issues. The databases and infrastructure created for the Vaccine Safety Datalink have also provided opportunities to address vaccination coverage, cost-effectiveness and other matters connected with immunization as well as matters outside this field.

Original languageEnglish (US)
Pages (from-to)186-194
Number of pages9
JournalBulletin of the World Health Organization
Volume78
Issue number2
StatePublished - Mar 27 2000

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Health Maintenance Organizations
Immunization
Vaccines
Safety
Research
Vaccination
Birth Certificates
Immunization Programs
Censuses
Centers for Disease Control and Prevention (U.S.)
Cost-Benefit Analysis
Hospital Emergency Service
Hospitalization
Outpatients
Databases
Population

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Chen, R. T., DeStefano, F., Davis, R. L., Jackson, L. A., Thompson, R. S., Mullooly, J. P., ... Caserta, V. (2000). The Vaccine Safety Datalink: Immunization research in health maintenance organizations in the USA. Bulletin of the World Health Organization, 78(2), 186-194.

The Vaccine Safety Datalink : Immunization research in health maintenance organizations in the USA. / Chen, R. T.; DeStefano, F.; Davis, R. L.; Jackson, L. A.; Thompson, R. S.; Mullooly, J. P.; Black, S. B.; Shinefield, H. R.; Vadheim, C. M.; Ward, J. I.; Marcy, S. M.; Glasser, J.; Rhodes, P. H.; Wassilak, S.; Kramarz, P.; Swint, E.; Walker, D.; Okoro, C.; Gargiullo, P.; Baughman, D.; King, D.; Benson, P.; Immanuel, V.; Barlow, W.; Bohlke, K.; Poy, P. L.; Rebolledo, V.; Rubanowice, D.; Mell, L.; Lafrance, M.; Huggins, L.; Dhillon, J.; Zavitkovsky, A.; Salazar, A.; Adams, E.; Shafer, M.; Sunderland, M.; Habanangas, J.; Drake, J.; Kramer, J.; Drew, L.; Olson, K.; Mesa, J.; Pearson, J. A.; Allison, M.; Bauck, A.; Redmond, N.; Lieu, T. A.; Ray, P.; Lewis, E.; Fireman, B. H.; Lee, H.; Jing, J.; Goff, N.; Marcy, S. M.; Lugg, M.; Braun, M. M.; Wise, R. P.; Salive, M. E.; Caserta, V.

In: Bulletin of the World Health Organization, Vol. 78, No. 2, 27.03.2000, p. 186-194.

Research output: Contribution to journalArticle

Chen, RT, DeStefano, F, Davis, RL, Jackson, LA, Thompson, RS, Mullooly, JP, Black, SB, Shinefield, HR, Vadheim, CM, Ward, JI, Marcy, SM, Glasser, J, Rhodes, PH, Wassilak, S, Kramarz, P, Swint, E, Walker, D, Okoro, C, Gargiullo, P, Baughman, D, King, D, Benson, P, Immanuel, V, Barlow, W, Bohlke, K, Poy, PL, Rebolledo, V, Rubanowice, D, Mell, L, Lafrance, M, Huggins, L, Dhillon, J, Zavitkovsky, A, Salazar, A, Adams, E, Shafer, M, Sunderland, M, Habanangas, J, Drake, J, Kramer, J, Drew, L, Olson, K, Mesa, J, Pearson, JA, Allison, M, Bauck, A, Redmond, N, Lieu, TA, Ray, P, Lewis, E, Fireman, BH, Lee, H, Jing, J, Goff, N, Marcy, SM, Lugg, M, Braun, MM, Wise, RP, Salive, ME & Caserta, V 2000, 'The Vaccine Safety Datalink: Immunization research in health maintenance organizations in the USA', Bulletin of the World Health Organization, vol. 78, no. 2, pp. 186-194.
Chen, R. T. ; DeStefano, F. ; Davis, R. L. ; Jackson, L. A. ; Thompson, R. S. ; Mullooly, J. P. ; Black, S. B. ; Shinefield, H. R. ; Vadheim, C. M. ; Ward, J. I. ; Marcy, S. M. ; Glasser, J. ; Rhodes, P. H. ; Wassilak, S. ; Kramarz, P. ; Swint, E. ; Walker, D. ; Okoro, C. ; Gargiullo, P. ; Baughman, D. ; King, D. ; Benson, P. ; Immanuel, V. ; Barlow, W. ; Bohlke, K. ; Poy, P. L. ; Rebolledo, V. ; Rubanowice, D. ; Mell, L. ; Lafrance, M. ; Huggins, L. ; Dhillon, J. ; Zavitkovsky, A. ; Salazar, A. ; Adams, E. ; Shafer, M. ; Sunderland, M. ; Habanangas, J. ; Drake, J. ; Kramer, J. ; Drew, L. ; Olson, K. ; Mesa, J. ; Pearson, J. A. ; Allison, M. ; Bauck, A. ; Redmond, N. ; Lieu, T. A. ; Ray, P. ; Lewis, E. ; Fireman, B. H. ; Lee, H. ; Jing, J. ; Goff, N. ; Marcy, S. M. ; Lugg, M. ; Braun, M. M. ; Wise, R. P. ; Salive, M. E. ; Caserta, V. / The Vaccine Safety Datalink : Immunization research in health maintenance organizations in the USA. In: Bulletin of the World Health Organization. 2000 ; Vol. 78, No. 2. pp. 186-194.
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abstract = "The Vaccine Safety Datalink is a collaborative project involving the National Immunization Program of the Centers for Disease Control and Prevention and several large health maintenance organizations in the USA. The project began in 1990 with the primary purpose of rigorously evaluating concerns about the safety of vaccines. Computerized data on vaccination, medical outcome (e.g. outpatient visits, emergency room visits, hospitalizations, and deaths) and covariates (e.g. birth certificates, census data) are prospectively collected and linked under joint protocol at multiple health maintenance organizations for analysis. Approximately 6 million persons (2{\%} of the population of the USA) are now members of health maintenance organizations participating in the Vaccine Safety Datalink, which has proved to be a valuable resource providing important information on a number of vaccine safety issues. The databases and infrastructure created for the Vaccine Safety Datalink have also provided opportunities to address vaccination coverage, cost-effectiveness and other matters connected with immunization as well as matters outside this field.",
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