The VITAL study and overall pooled analysis with the VIPS non-invasive stroke detection device

Christopher P. Kellner, Eric Sauvageau, Kenneth V. Snyder, Kyle M. Fargen, Adam Arthur, Raymond D. Turner, Andrei Alexandrov

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Introduction Effective triage of patients with emergent large vessel occlusion (ELVO) to endovascular therapy capable centers may decrease time to treatment and improve outcome for these patients. Here we performed a derivation study to evaluate the accuracy of a portable, non-invasive, and easy to use severe stroke detector. Methods The volumetric impedance phase shift spectroscopy (VIPS) device was used to assign a bioimpedance asymmetry score to 248 subjects across three cohorts, including 41 subjects presenting as acute stroke codes at a major comprehensive stroke center (CSC), 79 healthy volunteers, and 128 patients presenting to CSCs with a wide variety of brain pathology including additional stroke codes. Diagnostic parameters were calculated for the ability of the device to discern (1) severe stroke from minor stroke and (2) severe stroke from all other subjects. Patients with intracranial hardware were excluded from the analysis. Results The VIPS device was able to differentiate severe stroke from minor strokes with a sensitivity of 93% (95% CI 83 to 98), specificity of 92% (95% CI 75 to 99), and an area under the curve (AUC) of 0.93 (95% CI 0.85 to 0.97). The device was able to differentiate severe stroke from all other subjects with a sensitivity of 93% (95% CI 83 to 98), specificity of 87% (95% CI 81 to 92), and an AUC of 0.95 (95% CI 0.89 to 0.96). Conclusion The VIPS device is a portable, non-invasive, and easy to use tool that may aid in the detection of severe stroke, including ELVO, with a sensitivity of 93% and specificity of 92% in this derivation study. This device has the potential to improve the triage of patients suffering severe stroke.

Original languageEnglish (US)
Pages (from-to)1079-1084
Number of pages6
JournalJournal of neurointerventional surgery
Volume10
Issue number11
DOIs
StatePublished - Nov 1 2018

Fingerprint

Electric Impedance
Spectrum Analysis
Stroke
Equipment and Supplies
Triage
Area Under Curve
Healthy Volunteers
Pathology
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

The VITAL study and overall pooled analysis with the VIPS non-invasive stroke detection device. / Kellner, Christopher P.; Sauvageau, Eric; Snyder, Kenneth V.; Fargen, Kyle M.; Arthur, Adam; Turner, Raymond D.; Alexandrov, Andrei.

In: Journal of neurointerventional surgery, Vol. 10, No. 11, 01.11.2018, p. 1079-1084.

Research output: Contribution to journalArticle

Kellner, Christopher P. ; Sauvageau, Eric ; Snyder, Kenneth V. ; Fargen, Kyle M. ; Arthur, Adam ; Turner, Raymond D. ; Alexandrov, Andrei. / The VITAL study and overall pooled analysis with the VIPS non-invasive stroke detection device. In: Journal of neurointerventional surgery. 2018 ; Vol. 10, No. 11. pp. 1079-1084.
@article{e2587debe68543babd754e9a3196513b,
title = "The VITAL study and overall pooled analysis with the VIPS non-invasive stroke detection device",
abstract = "Introduction Effective triage of patients with emergent large vessel occlusion (ELVO) to endovascular therapy capable centers may decrease time to treatment and improve outcome for these patients. Here we performed a derivation study to evaluate the accuracy of a portable, non-invasive, and easy to use severe stroke detector. Methods The volumetric impedance phase shift spectroscopy (VIPS) device was used to assign a bioimpedance asymmetry score to 248 subjects across three cohorts, including 41 subjects presenting as acute stroke codes at a major comprehensive stroke center (CSC), 79 healthy volunteers, and 128 patients presenting to CSCs with a wide variety of brain pathology including additional stroke codes. Diagnostic parameters were calculated for the ability of the device to discern (1) severe stroke from minor stroke and (2) severe stroke from all other subjects. Patients with intracranial hardware were excluded from the analysis. Results The VIPS device was able to differentiate severe stroke from minor strokes with a sensitivity of 93{\%} (95{\%} CI 83 to 98), specificity of 92{\%} (95{\%} CI 75 to 99), and an area under the curve (AUC) of 0.93 (95{\%} CI 0.85 to 0.97). The device was able to differentiate severe stroke from all other subjects with a sensitivity of 93{\%} (95{\%} CI 83 to 98), specificity of 87{\%} (95{\%} CI 81 to 92), and an AUC of 0.95 (95{\%} CI 0.89 to 0.96). Conclusion The VIPS device is a portable, non-invasive, and easy to use tool that may aid in the detection of severe stroke, including ELVO, with a sensitivity of 93{\%} and specificity of 92{\%} in this derivation study. This device has the potential to improve the triage of patients suffering severe stroke.",
author = "Kellner, {Christopher P.} and Eric Sauvageau and Snyder, {Kenneth V.} and Fargen, {Kyle M.} and Adam Arthur and Turner, {Raymond D.} and Andrei Alexandrov",
year = "2018",
month = "11",
day = "1",
doi = "10.1136/neurintsurg-2017-013690",
language = "English (US)",
volume = "10",
pages = "1079--1084",
journal = "Journal of NeuroInterventional Surgery",
issn = "1759-8478",
publisher = "BMJ Publishing Group",
number = "11",

}

TY - JOUR

T1 - The VITAL study and overall pooled analysis with the VIPS non-invasive stroke detection device

AU - Kellner, Christopher P.

AU - Sauvageau, Eric

AU - Snyder, Kenneth V.

AU - Fargen, Kyle M.

AU - Arthur, Adam

AU - Turner, Raymond D.

AU - Alexandrov, Andrei

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Introduction Effective triage of patients with emergent large vessel occlusion (ELVO) to endovascular therapy capable centers may decrease time to treatment and improve outcome for these patients. Here we performed a derivation study to evaluate the accuracy of a portable, non-invasive, and easy to use severe stroke detector. Methods The volumetric impedance phase shift spectroscopy (VIPS) device was used to assign a bioimpedance asymmetry score to 248 subjects across three cohorts, including 41 subjects presenting as acute stroke codes at a major comprehensive stroke center (CSC), 79 healthy volunteers, and 128 patients presenting to CSCs with a wide variety of brain pathology including additional stroke codes. Diagnostic parameters were calculated for the ability of the device to discern (1) severe stroke from minor stroke and (2) severe stroke from all other subjects. Patients with intracranial hardware were excluded from the analysis. Results The VIPS device was able to differentiate severe stroke from minor strokes with a sensitivity of 93% (95% CI 83 to 98), specificity of 92% (95% CI 75 to 99), and an area under the curve (AUC) of 0.93 (95% CI 0.85 to 0.97). The device was able to differentiate severe stroke from all other subjects with a sensitivity of 93% (95% CI 83 to 98), specificity of 87% (95% CI 81 to 92), and an AUC of 0.95 (95% CI 0.89 to 0.96). Conclusion The VIPS device is a portable, non-invasive, and easy to use tool that may aid in the detection of severe stroke, including ELVO, with a sensitivity of 93% and specificity of 92% in this derivation study. This device has the potential to improve the triage of patients suffering severe stroke.

AB - Introduction Effective triage of patients with emergent large vessel occlusion (ELVO) to endovascular therapy capable centers may decrease time to treatment and improve outcome for these patients. Here we performed a derivation study to evaluate the accuracy of a portable, non-invasive, and easy to use severe stroke detector. Methods The volumetric impedance phase shift spectroscopy (VIPS) device was used to assign a bioimpedance asymmetry score to 248 subjects across three cohorts, including 41 subjects presenting as acute stroke codes at a major comprehensive stroke center (CSC), 79 healthy volunteers, and 128 patients presenting to CSCs with a wide variety of brain pathology including additional stroke codes. Diagnostic parameters were calculated for the ability of the device to discern (1) severe stroke from minor stroke and (2) severe stroke from all other subjects. Patients with intracranial hardware were excluded from the analysis. Results The VIPS device was able to differentiate severe stroke from minor strokes with a sensitivity of 93% (95% CI 83 to 98), specificity of 92% (95% CI 75 to 99), and an area under the curve (AUC) of 0.93 (95% CI 0.85 to 0.97). The device was able to differentiate severe stroke from all other subjects with a sensitivity of 93% (95% CI 83 to 98), specificity of 87% (95% CI 81 to 92), and an AUC of 0.95 (95% CI 0.89 to 0.96). Conclusion The VIPS device is a portable, non-invasive, and easy to use tool that may aid in the detection of severe stroke, including ELVO, with a sensitivity of 93% and specificity of 92% in this derivation study. This device has the potential to improve the triage of patients suffering severe stroke.

UR - http://www.scopus.com/inward/record.url?scp=85049167643&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049167643&partnerID=8YFLogxK

U2 - 10.1136/neurintsurg-2017-013690

DO - 10.1136/neurintsurg-2017-013690

M3 - Article

VL - 10

SP - 1079

EP - 1084

JO - Journal of NeuroInterventional Surgery

JF - Journal of NeuroInterventional Surgery

SN - 1759-8478

IS - 11

ER -