The World Health Organisation 2016 classification of penile carcinomas

a review and update from the International Society of Urological Pathology expert-driven recommendations

Members of the ISUP Penile Tumor Panel

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

The International Society of Urological Pathology (ISUP) held an expert-driven penile cancer conference in Boston in March 2015, which focused on the new World Health Organisation (WHO) classification of penile cancer: human papillomavirus (HPV)-related tumours and histological grading. The conference was preceded by an online survey of the ISUP members, and the results were used to initiate discussions. Because of the rarity of penile tumours, this was not a consensus but an expert-driven conference aimed at assisting pathologists who do not see these tumours on a regular basis. After a justification for the novel separation of penile squamous cell carcinomas into HPV-related and non-HPV-related-carcinomas, the histological classification of penile carcinoma was proposed; this system was also accepted subsequently by the WHO for subtyping of penile carcinomas (2016). A description of HPV-related neoplasms, which may be recognised by their histological features, was presented, and p16 was recommended as a surrogate indicator of HPV. A three-tier grading system was recommended for penile squamous carcinomas; this was also adopted by the WHO (2016). Many of the distinctive histological subtypes of squamous cell carcinoma of the penis are associated with distinct grades, based on the squamous cell carcinoma subtype histological features.

Original languageEnglish (US)
Pages (from-to)893-904
Number of pages12
JournalHistopathology
Volume72
Issue number6
DOIs
StatePublished - May 1 2018

Fingerprint

Squamous Cell Carcinoma
Penile Neoplasms
Pathology
Carcinoma
Neoplasms
Neoplasm Grading
Penis

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

Cite this

The World Health Organisation 2016 classification of penile carcinomas : a review and update from the International Society of Urological Pathology expert-driven recommendations. / Members of the ISUP Penile Tumor Panel.

In: Histopathology, Vol. 72, No. 6, 01.05.2018, p. 893-904.

Research output: Contribution to journalReview article

@article{20cb8d1aa1a84e6abd79f739627a5008,
title = "The World Health Organisation 2016 classification of penile carcinomas: a review and update from the International Society of Urological Pathology expert-driven recommendations",
abstract = "The International Society of Urological Pathology (ISUP) held an expert-driven penile cancer conference in Boston in March 2015, which focused on the new World Health Organisation (WHO) classification of penile cancer: human papillomavirus (HPV)-related tumours and histological grading. The conference was preceded by an online survey of the ISUP members, and the results were used to initiate discussions. Because of the rarity of penile tumours, this was not a consensus but an expert-driven conference aimed at assisting pathologists who do not see these tumours on a regular basis. After a justification for the novel separation of penile squamous cell carcinomas into HPV-related and non-HPV-related-carcinomas, the histological classification of penile carcinoma was proposed; this system was also accepted subsequently by the WHO for subtyping of penile carcinomas (2016). A description of HPV-related neoplasms, which may be recognised by their histological features, was presented, and p16 was recommended as a surrogate indicator of HPV. A three-tier grading system was recommended for penile squamous carcinomas; this was also adopted by the WHO (2016). Many of the distinctive histological subtypes of squamous cell carcinoma of the penis are associated with distinct grades, based on the squamous cell carcinoma subtype histological features.",
author = "{Members of the ISUP Penile Tumor Panel} and Cubilla, {Antonio L.} and Velazquez, {Elsa F.} and Mahul Amin and Jonathan Epstein and Berney, {Daniel M.} and Corbishley, {Cathy M.}",
year = "2018",
month = "5",
day = "1",
doi = "10.1111/his.13429",
language = "English (US)",
volume = "72",
pages = "893--904",
journal = "Histopathology",
issn = "0309-0167",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - The World Health Organisation 2016 classification of penile carcinomas

T2 - a review and update from the International Society of Urological Pathology expert-driven recommendations

AU - Members of the ISUP Penile Tumor Panel

AU - Cubilla, Antonio L.

AU - Velazquez, Elsa F.

AU - Amin, Mahul

AU - Epstein, Jonathan

AU - Berney, Daniel M.

AU - Corbishley, Cathy M.

PY - 2018/5/1

Y1 - 2018/5/1

N2 - The International Society of Urological Pathology (ISUP) held an expert-driven penile cancer conference in Boston in March 2015, which focused on the new World Health Organisation (WHO) classification of penile cancer: human papillomavirus (HPV)-related tumours and histological grading. The conference was preceded by an online survey of the ISUP members, and the results were used to initiate discussions. Because of the rarity of penile tumours, this was not a consensus but an expert-driven conference aimed at assisting pathologists who do not see these tumours on a regular basis. After a justification for the novel separation of penile squamous cell carcinomas into HPV-related and non-HPV-related-carcinomas, the histological classification of penile carcinoma was proposed; this system was also accepted subsequently by the WHO for subtyping of penile carcinomas (2016). A description of HPV-related neoplasms, which may be recognised by their histological features, was presented, and p16 was recommended as a surrogate indicator of HPV. A three-tier grading system was recommended for penile squamous carcinomas; this was also adopted by the WHO (2016). Many of the distinctive histological subtypes of squamous cell carcinoma of the penis are associated with distinct grades, based on the squamous cell carcinoma subtype histological features.

AB - The International Society of Urological Pathology (ISUP) held an expert-driven penile cancer conference in Boston in March 2015, which focused on the new World Health Organisation (WHO) classification of penile cancer: human papillomavirus (HPV)-related tumours and histological grading. The conference was preceded by an online survey of the ISUP members, and the results were used to initiate discussions. Because of the rarity of penile tumours, this was not a consensus but an expert-driven conference aimed at assisting pathologists who do not see these tumours on a regular basis. After a justification for the novel separation of penile squamous cell carcinomas into HPV-related and non-HPV-related-carcinomas, the histological classification of penile carcinoma was proposed; this system was also accepted subsequently by the WHO for subtyping of penile carcinomas (2016). A description of HPV-related neoplasms, which may be recognised by their histological features, was presented, and p16 was recommended as a surrogate indicator of HPV. A three-tier grading system was recommended for penile squamous carcinomas; this was also adopted by the WHO (2016). Many of the distinctive histological subtypes of squamous cell carcinoma of the penis are associated with distinct grades, based on the squamous cell carcinoma subtype histological features.

UR - http://www.scopus.com/inward/record.url?scp=85041714855&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041714855&partnerID=8YFLogxK

U2 - 10.1111/his.13429

DO - 10.1111/his.13429

M3 - Review article

VL - 72

SP - 893

EP - 904

JO - Histopathology

JF - Histopathology

SN - 0309-0167

IS - 6

ER -