The yeast UME6 gene product is required for transcriptional repression mediated by the CAR1 URS1 repressor binding site

Heui Dong Park, Ralf M. Luche, Terrance Cooper

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

URS1 Is known to be a repressor binding site In Saccharomyces cerevisiae that negatively regulates expression of many genes including CAR1 (arginase), several required for sporulation, mating type switching, inositol metabolism, and oxidative carbon metabolism. In addition to the proteins previously shown to directly bind to the URS1 site, we show here that the UME6 gene product is required for URS1 to mediate repression of gene expression In the absence of Inducer. We also show that mutations in the CAR80 (CARGRI) gene are allelic to those in UME6.

Original languageEnglish (US)
Pages (from-to)1909-1915
Number of pages7
JournalNucleic acids research
Volume20
Issue number8
DOIs
StatePublished - Apr 25 1992

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Yeasts
Binding Sites
Gene Expression
Arginase
Inositol
Genes
Saccharomyces cerevisiae
Carbon
Mutation
Proteins

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

The yeast UME6 gene product is required for transcriptional repression mediated by the CAR1 URS1 repressor binding site. / Park, Heui Dong; Luche, Ralf M.; Cooper, Terrance.

In: Nucleic acids research, Vol. 20, No. 8, 25.04.1992, p. 1909-1915.

Research output: Contribution to journalArticle

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