Therapeutic Efficacy of Antiepileptic Drugs

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter primarily focuses on the efficacy of antiepileptic drugs, while realizing that many other factors are critical in drug selection (e.g., adverse effect profile, pharmacology, etc.). The challenge the clinician faces is selecting the antiepileptic drug that is efficacious for a given seizure type or epilepsy syndrome, and applying the results of large population-based studies to their individual patient. The importance of the correct diagnosis cannot be overstated. Current efficacy-based treatment guidelines and algorithms are described, as are drug therapies that have regulatory approval in children, antiepileptic drugs for which randomized controlled trials have been conducted in a given epilepsy syndrome, and recommendations for treatment using the expert consensus method. Drug selection for specific pediatric epilepsy syndromes, and how choices can be affected by comorbidities, are considered.

Original languageEnglish (US)
Title of host publicationEpilepsy in Children and Adolescents
PublisherJohn Wiley and Sons
Pages159-174
Number of pages16
ISBN (Print)9780470741238
DOIs
StatePublished - Nov 1 2012

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Anticonvulsants
Epilepsy
Pharmaceutical Preparations
Comorbidity
Seizures
Therapeutics
Randomized Controlled Trials
Pharmacology
Guidelines
Pediatrics
Drug Therapy
Population

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Wheless, J. (2012). Therapeutic Efficacy of Antiepileptic Drugs. In Epilepsy in Children and Adolescents (pp. 159-174). John Wiley and Sons. https://doi.org/10.1002/9781119998600.ch10

Therapeutic Efficacy of Antiepileptic Drugs. / Wheless, James.

Epilepsy in Children and Adolescents. John Wiley and Sons, 2012. p. 159-174.

Research output: Chapter in Book/Report/Conference proceedingChapter

Wheless, J 2012, Therapeutic Efficacy of Antiepileptic Drugs. in Epilepsy in Children and Adolescents. John Wiley and Sons, pp. 159-174. https://doi.org/10.1002/9781119998600.ch10
Wheless J. Therapeutic Efficacy of Antiepileptic Drugs. In Epilepsy in Children and Adolescents. John Wiley and Sons. 2012. p. 159-174 https://doi.org/10.1002/9781119998600.ch10
Wheless, James. / Therapeutic Efficacy of Antiepileptic Drugs. Epilepsy in Children and Adolescents. John Wiley and Sons, 2012. pp. 159-174
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