There is no association between cardiovascular autonomic dysfunction and peripheral neuropathy in chronic hemodialysis patients

Elefterios Stamboulis, Konstantinos Voumvourakis, Thomas Zambelis, Athina Andrikopoulou, Demetrios Vlahakos, Athanasios Tsivgoulis, Demetrios Rallis, Georgios Tsivgoulis

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background and Purpose The potential association between the severity of autonomic dysfunction and peripheral neuropathy has not been extensively investigated, with the few studies yielding inconsistent results. We evaluated the relationship between autonomic dysfunction and peripheral neuropathy in chronic hemodialysis patients in a cross-sectional study. Methods Cardiovascular autonomic function was assessed in 42 consecutive patients with chronic renal failure treated by hemodialysis, using a standardized battery of 5 cardiovascular reflex tests. Symptoms of autonomic dysfunction and of peripheral neuropathy were evaluated using the Autonomic Neuropathy Symptom Score (ANSS) and the Neuropathy Symptoms Score. Neurological deficits were assessed using the Neuropathy Disability Score. Conduction velocities along the sensory and motor fibers of the sural and peroneal nerves were measured. Thermal thresholds were documented using a standardized psychophysical technique. Results Parasympathetic and sympathetic dysfunction was prevalent in 50% and 28% of cases, respectively. Peripheral neuropathy was identified in 25 cases (60%). The prevalence of peripheral neuropathy did not differ between patients with impaired (55%) and normal (75%) autonomic function (p=0.297; Fisher's exact test). The electrophysiological parameters for peripheral nerve function, neuropathic symptoms, abnormal thermal thresholds, age, gender, and duration of dialysis did not differ significantly between patients with and without autonomic dysfunction. Patients with autonomic dysfunction were more likely to have an abnormal ANSS (p=0.048). The severity of autonomic dysfunction on electrophysiological testing was positively correlated with ANSS (r=0.213, p=0.036). Conclusions The present data indicate that although cardiovascular autonomic dysfunction is prevalent among patients with chronic renal failure, it is not associated with the incidence of peripheral neuropathy.

Original languageEnglish (US)
Pages (from-to)143-147
Number of pages5
JournalJournal of Clinical Neurology (Korea)
Volume6
Issue number3
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

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Peripheral Nervous System Diseases
Renal Dialysis
Chronic Kidney Failure
Hot Temperature
Sural Nerve
Peroneal Nerve
Peripheral Nerves
Reflex
Dialysis
Cross-Sectional Studies
Incidence

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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There is no association between cardiovascular autonomic dysfunction and peripheral neuropathy in chronic hemodialysis patients. / Stamboulis, Elefterios; Voumvourakis, Konstantinos; Zambelis, Thomas; Andrikopoulou, Athina; Vlahakos, Demetrios; Tsivgoulis, Athanasios; Rallis, Demetrios; Tsivgoulis, Georgios.

In: Journal of Clinical Neurology (Korea), Vol. 6, No. 3, 01.01.2010, p. 143-147.

Research output: Contribution to journalArticle

Stamboulis, Elefterios ; Voumvourakis, Konstantinos ; Zambelis, Thomas ; Andrikopoulou, Athina ; Vlahakos, Demetrios ; Tsivgoulis, Athanasios ; Rallis, Demetrios ; Tsivgoulis, Georgios. / There is no association between cardiovascular autonomic dysfunction and peripheral neuropathy in chronic hemodialysis patients. In: Journal of Clinical Neurology (Korea). 2010 ; Vol. 6, No. 3. pp. 143-147.
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