Thermal hyperalgesia after sciatic nerve block in rat is transient and clinically insignificant

Allison Janda, Ralph Lydic, Kathleen B. Welch, Chad M. Brummett

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Ropivacaine has been associated with transient heat hyperalgesia in sciatic nerve blocks in rat. The goal of the present study was to evaluate the hypothesized presence of transient heat hyperalgesia after perineural injection of ropivacaine with a secondary subanalysis of 2 published studies. Paw withdrawal latency was used to assess the duration of sensory blockade and presence of heat hyperalgesia at 210, 240, 270, and 300 minutes and 24 hours after injection. The analysis revealed hyperalgesia at a single time point (240 minutes after injection; mean difference,-0.60 seconds; P = 0.012) that resolved within 30 minutes, and there was no other significant hyperalgesia at other time points. Although statistically significant, the single time point measurement represented only an 11% change from baseline and was no longer present 30 minutes later. These data support the need for a reevaluation of the interpretation that pain can be worsened by perineural ropivacaine injection.

Original languageEnglish (US)
Pages (from-to)151-154
Number of pages4
JournalRegional Anesthesia and Pain Medicine
Volume38
Issue number2
DOIs
StatePublished - Mar 1 2013
Externally publishedYes

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Nerve Block
Hyperalgesia
Sciatic Nerve
Injections
Hot Temperature
Pain
ropivacaine

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

Thermal hyperalgesia after sciatic nerve block in rat is transient and clinically insignificant. / Janda, Allison; Lydic, Ralph; Welch, Kathleen B.; Brummett, Chad M.

In: Regional Anesthesia and Pain Medicine, Vol. 38, No. 2, 01.03.2013, p. 151-154.

Research output: Contribution to journalArticle

Janda, Allison ; Lydic, Ralph ; Welch, Kathleen B. ; Brummett, Chad M. / Thermal hyperalgesia after sciatic nerve block in rat is transient and clinically insignificant. In: Regional Anesthesia and Pain Medicine. 2013 ; Vol. 38, No. 2. pp. 151-154.
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