Thermoregulatory dysfunction in Parkinson's disease

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Homeotherms, such as humans with Parkinson's disease, must maintain core body temperature in a narrow range in the face of fluctuating environmental surroundings and endogenous heat production. A complex and highly integrated collection of autonomic, endocrine, and behavioral responses are involved in the maintenance of core temperature. Dopaminergic innervation of the preoptic and anterior hypothalamus plays an important role in the central nervous system's control of body temperature. Due to a combination of central dopamine deficiency and peripheral autonomic dysfunction, individuals with Parkinson's disease may experience heat and/or cold intolerance and paroxysmal hyperhidrosis. Sudomotor dysfunction in Parkinson's disease can be documented with the sympathetic skin response and quantitative sudomotor axon re flex and thermoregulatory sweat tests.

Original languageEnglish (US)
Title of host publicationParkinson's Disease and Nonmotor Dysfunction
Subtitle of host publicationSecond Edition
PublisherHumana Press Inc.
Pages213-227
Number of pages15
ISBN (Electronic)9781607614296
ISBN (Print)9781607614289
DOIs
StatePublished - Jan 1 2013

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Parkinson Disease
Body Temperature
Hyperhidrosis
Anterior Hypothalamus
Sweat
Thermogenesis
Axons
Dopamine
Central Nervous System
Hot Temperature
Maintenance
Skin
Temperature

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Ledoux, M. (2013). Thermoregulatory dysfunction in Parkinson's disease. In Parkinson's Disease and Nonmotor Dysfunction: Second Edition (pp. 213-227). Humana Press Inc.. https://doi.org/10.1007/978-1-60761-429-6_14

Thermoregulatory dysfunction in Parkinson's disease. / Ledoux, Mark.

Parkinson's Disease and Nonmotor Dysfunction: Second Edition. Humana Press Inc., 2013. p. 213-227.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ledoux, M 2013, Thermoregulatory dysfunction in Parkinson's disease. in Parkinson's Disease and Nonmotor Dysfunction: Second Edition. Humana Press Inc., pp. 213-227. https://doi.org/10.1007/978-1-60761-429-6_14
Ledoux M. Thermoregulatory dysfunction in Parkinson's disease. In Parkinson's Disease and Nonmotor Dysfunction: Second Edition. Humana Press Inc. 2013. p. 213-227 https://doi.org/10.1007/978-1-60761-429-6_14
Ledoux, Mark. / Thermoregulatory dysfunction in Parkinson's disease. Parkinson's Disease and Nonmotor Dysfunction: Second Edition. Humana Press Inc., 2013. pp. 213-227
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