Thermoresponsive and biodegradable hydrogels for sustained release of nerve growth factor to stimulate neurite outgrowth

Xiao Huang, Linfeng Wu, Xiaoxun Li, Tao Lowe

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A series of thermoresponsive and biodegradable hydrogels were developed for sustained release of nerve growth factor (NGF) for ultimate goal of treating neurological disorders. These hydrogels were composed of poly(N- isopropylacrylamide) (PNIPAAm) as a thermoresponsive unit, poly(L-lactic acid) (PLLA) as a hydrolytically degradable and hydrophobic unit, and dextran as an enzymatically degradable and hydrophilic unit. NGF was loaded into these hydrogels in aqueous solution with various loading efficiencies depending on the compositions of hydrogels. In-vitro release study showed that the release of NGF from these hydrogels could last for at least 15 days. NGF released from the hydrogels was able to stimulate neurite growth from PC12 cells.

Original languageEnglish (US)
Pages (from-to)301-309
Number of pages9
JournalMacromolecular Symposia
Volume317-318
Issue number1
DOIs
StatePublished - Aug 2012

Fingerprint

Hydrogels
nerves
Nerve Growth Factor
dextrans
lactic acid
Dextran
Lactic acid
Dextrans
Intercellular Signaling Peptides and Proteins
disorders
aqueous solutions
cells
Chemical analysis

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics
  • Condensed Matter Physics

Cite this

Thermoresponsive and biodegradable hydrogels for sustained release of nerve growth factor to stimulate neurite outgrowth. / Huang, Xiao; Wu, Linfeng; Li, Xiaoxun; Lowe, Tao.

In: Macromolecular Symposia, Vol. 317-318, No. 1, 08.2012, p. 301-309.

Research output: Contribution to journalArticle

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