Thrombocytopenia in preeclampsia

Associated abnormalities and management principles

Siva Thiagarajah, F. John Bourgeois, Guy M. Harbert, Michael Caudle

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

Severe thrombocytopenia, abnormal liver function, and renal dysfunction may occur as manifestations of preeclampsia. Failure to recognize that this cluster of abnormalities represents a form of preeclampsia may result in erroneous initial diagnoses. Management of 13 such patients has shown a direct correlation between the degree of thrombocytopenia and the measures of liver dysfunction. Platelet counts and liver functions improved prior to delivery in five patients treated with corticosteroids. Management should be directed toward investigation and correction of deranged physiology and appropriate monitoring of maternal-feto-placental status. Early delivery is indicated in patients with progressive thrombocytopenia and in those with evidence of fetal maturity or distress. Provided that the disease process remains stable, consideration should be given in cases of fetal immaturity, to the use of betamethasone therapy. The occurrence of severe thrombocytopenia in 20% of neonates should be a consideration in selecting the mode of delivery.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume150
Issue number1
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

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Pre-Eclampsia
Thrombocytopenia
Betamethasone
Liver
Platelet Count
Liver Diseases
Adrenal Cortex Hormones
Mothers
Newborn Infant
Kidney
Therapeutics

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Thrombocytopenia in preeclampsia : Associated abnormalities and management principles. / Thiagarajah, Siva; Bourgeois, F. John; Harbert, Guy M.; Caudle, Michael.

In: American Journal of Obstetrics and Gynecology, Vol. 150, No. 1, 01.01.1984, p. 1-7.

Research output: Contribution to journalArticle

Thiagarajah, Siva ; Bourgeois, F. John ; Harbert, Guy M. ; Caudle, Michael. / Thrombocytopenia in preeclampsia : Associated abnormalities and management principles. In: American Journal of Obstetrics and Gynecology. 1984 ; Vol. 150, No. 1. pp. 1-7.
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