Thy-1 differentiation protein and monocyte-derived cells during regeneration and aging of human placental villi

Antonin Bukovsky, Michael Caudle, Jeffrey Keenan, J. Wimalasena, P. P. McKenzie

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

PROBLEM: The classification of placental villi was reviewed, and regeneration of villous trees in mature human placentae was examined. METHOD OF STUDY: Expression of Thy-1 by placental fibroblasts and pericytes and markers of endothelial cells and monocyte-derived cells were studied by immunohistochemistry and image analysis. RESULTS: Villous regeneration consists of (i) dedifferentiation of mature ramuli into young stem villi producing mesenchymal villi: (ii) differentiation of mesenchymal villi into immature intermediate villi; and (iii) differentiation of immature intermediate villi into transitory intermediate villi, branching into the precursors of mature intermediate and terminal villi. These processes are associated with dedifferentiation and redifferentiation of placental monocyte-derived cells. Significant changes of Thy-1 expression by fibroblasts and pericytes accompany aging and degeneration, as well as regeneration of placental villi. CONCLUSIONS: Villous aging and degeneration in normal mature human placenta is compensated by regeneration of villous trees. Lack of villous regeneration may cause chronic fetal distress, due to the increasing demands of the growing fetus on the remaining terminal villi.

Original languageEnglish (US)
Pages (from-to)135-152
Number of pages18
JournalAmerican Journal of Reproductive Immunology
Volume42
Issue number3
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

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Chorionic Villi
Regeneration
Monocytes
Pericytes
Proteins
Placenta
Fibroblasts
Fetal Distress
Fetus
Endothelial Cells
Immunohistochemistry

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Thy-1 differentiation protein and monocyte-derived cells during regeneration and aging of human placental villi. / Bukovsky, Antonin; Caudle, Michael; Keenan, Jeffrey; Wimalasena, J.; McKenzie, P. P.

In: American Journal of Reproductive Immunology, Vol. 42, No. 3, 01.01.1999, p. 135-152.

Research output: Contribution to journalArticle

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AU - Keenan, Jeffrey

AU - Wimalasena, J.

AU - McKenzie, P. P.

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