Thyroid function during pregnancy

Corinne R. Fantz, Samuel Dagogo-Jack, Jack H. Ladenson, Ann M. Gronowski

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Background: This Case Conference reviews the normal changes in thyroid activity that occur outing pregnancy and the proper use of laboratory tests for the diagnosis of thyroid dysfunction in the pregnant patient. Case: A woman in the 18th week of pregnancy presented with tachycardia, increased blood pressure, severe vomiting, increased total and free thyroid hormone concentrations, a thyroid-stimulating hormone (TSH) concentration within the reference interval, and an increased human chorionic gonadotropin (hCG) β- subunit concentration. Issues: During pregnancy, normal thyroid activity undergoes significant changes, including a two- to threefold increase in thyroxine-binding globulin concentrations, a 30-100% increase in total triiodothyronine and thyroxine concentrations, increased serum thyroglobulin, and increased renal iodide clearance. Furthermore, hCG has mild thyroid stimulating activity. Pregnancy produces an overall increase in thyroid activity, which allows the healthy individual to remain in a net euthyroid state. However, both hyper- and hypothyroidism can occur in pregnant patients. In addition, two pregnancy-specific conditions, hyperemesis gravidarum and gestational trophoblastic disease, can lead to clinical hyperthyroidism. The normal changes in thyroid activity and the association of pregnancy with conditions that can cause hyperthyroidism necessitates careful interpretation of thyroid function tests during pregnancy. Conclusion: Assessment of thyroid function during pregnancy should be done with a careful clinical evaluation of the patient's symptoms as well as measurement of TSH and free, not total, thyroid hormones. Measurement of thyroid autoantibodies may also be useful in selected cases to detect maternal Graves disease or Hashimoro thyroiditis and to assess risk of fetal or neonatal consequences of maternal thyroid dysfunction.

Original languageEnglish (US)
Pages (from-to)2250-2258
Number of pages9
JournalClinical Chemistry
Volume45
Issue number12
StatePublished - 1999
Externally publishedYes

Fingerprint

Thyrotropin
Chorionic Gonadotropin
Thyroid Hormones
Thyroid Gland
Thyroxine-Binding Globulin
Pregnancy
Thyroglobulin
Blood pressure
Iodides
Triiodothyronine
Thyroxine
Autoantibodies
Hyperthyroidism
Mothers
Hyperemesis Gravidarum
Gestational Trophoblastic Disease
Thyroid Function Tests
Thyroiditis
Symptom Assessment
Clinical Laboratory Techniques

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Fantz, C. R., Dagogo-Jack, S., Ladenson, J. H., & Gronowski, A. M. (1999). Thyroid function during pregnancy. Clinical Chemistry, 45(12), 2250-2258.

Thyroid function during pregnancy. / Fantz, Corinne R.; Dagogo-Jack, Samuel; Ladenson, Jack H.; Gronowski, Ann M.

In: Clinical Chemistry, Vol. 45, No. 12, 1999, p. 2250-2258.

Research output: Contribution to journalArticle

Fantz, CR, Dagogo-Jack, S, Ladenson, JH & Gronowski, AM 1999, 'Thyroid function during pregnancy', Clinical Chemistry, vol. 45, no. 12, pp. 2250-2258.
Fantz CR, Dagogo-Jack S, Ladenson JH, Gronowski AM. Thyroid function during pregnancy. Clinical Chemistry. 1999;45(12):2250-2258.
Fantz, Corinne R. ; Dagogo-Jack, Samuel ; Ladenson, Jack H. ; Gronowski, Ann M. / Thyroid function during pregnancy. In: Clinical Chemistry. 1999 ; Vol. 45, No. 12. pp. 2250-2258.
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