Thyroid hormone status regulates the expression of secretory phospholipases

Pragya Sharma, Tania Levesque, Eric Boilard, Edwards Park

Research output: Contribution to journalArticle

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Abstract

Thyroid hormone (T3) stimulates various metabolic pathways and the hepatic actions of T3 are mediated primarily through the thyroid hormone receptor beta (TRβ). Hypothyroidism has been linked with low grade inflammation, elevated risk of hepatic steatosis and atherosclerosis. Secretory phospholipases (sPLA2) are associated with inflammation, hyperlipidemia and atherosclerosis. Due to potential linkage between thyroid hormone and sPLA2, we investigated the effect of thyroid hormone status on the regulation of secretory phospholipases in mice, rats and human liver. T3 suppressed the expression of the sPLA2 group IIa (PLA2g2a) gene in the liver of BALB/c mice and C57BL/6 transgenic mice expressing the human PLA2g2a. PLA2g2a was elevated with hypothyroidism and high fat diets which may contribute to the low grade inflammation associated with hypothyroidism and diet induced obesity. We also examined the effects of the TRβ agonist eprotirome on hepatic gene regulation. We observed that eprotirome inhibited the expression of selected sPLA2 genes and furthermore the cytokine mediated induction PLA2g2a was suppressed. In addition, eprotirome induced genes involved in fatty acid oxidation and cholesterol clearance while inhibiting lipogenic genes. Our results indicate that in vivo thyroid hormone status regulates the abundance of sPLA2 and the inhibition of PLA2g2a by T3 is conserved across species. By regulating sPLA2 genes, T3 may impact processes associated with atherosclerosis and inflammation and TRβ agonists may ameliorate inflammation and hyperlipidemia.

Original languageEnglish (US)
Pages (from-to)56-62
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume444
Issue number1
DOIs
StatePublished - Jan 31 2014

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Phospholipases
Thyroid Hormones
Genes
Inflammation
Hypothyroidism
Liver
Atherosclerosis
Nutrition
Hyperlipidemias
Thyroid Hormone Receptors beta
Triiodothyronine
Gene expression
High Fat Diet
Rats
Metabolic Networks and Pathways
Inbred C57BL Mouse
Fatty Acids
Transgenic Mice
Fats
Cholesterol

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Thyroid hormone status regulates the expression of secretory phospholipases. / Sharma, Pragya; Levesque, Tania; Boilard, Eric; Park, Edwards.

In: Biochemical and Biophysical Research Communications, Vol. 444, No. 1, 31.01.2014, p. 56-62.

Research output: Contribution to journalArticle

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