Thyroid-like follicular carcinoma of the kidney

One case report and review of the literature

Rahul Dawane, Alan Grindstaff, Anil V. Parwani, Timothy Brock, Wesley White, Laurentia Nodit

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objectives: Thyroid-like follicular carcinoma of the kidney continues to confound the practicing pathologist with its close resemblance to the follicular variant of thyroid carcinoma, as well as other benign and malignant entities. Our goal is to expand the knowledge of this rare renal cell carcinoma subtype, which is morphologically similar to follicular carcinoma of the thyroid but lacks expression of characteristic thyroid immunohistochemical markers such as TTF-1 and thyroglobulin. Methods: We evaluated the gross, histologic, immunohistochemical, and fluorescence in situ hybridization (FISH) studies of a new case and performed a comprehensive review of the literature. Results: The lesion was spongy and well-circumscribed. Microscopically it showed variably sized follicular structures, filled with abundant, deeply eosinophilic, colloidlike material. At the periphery, it displayed areas resembling metanephric adenoma and early stages of nephrogenesis. The tumor cells strongly expressed CK7, PAX-8, PAX-2, vimentin, EMA, and CK19 immunostains. Other markers, such as CD10, RCC, HBME-1, thyroglobulin, and TTF-1, were not immunoreactive. The tumor was negative for trisomy of both 7 and 17 and showed borderline monosomies (losses) of both chromosomes in FISH studies. Conclusions: Five years of preoperative observation and lack of recurrence bring further insight into the slow progressive nature of this neoplasm and support a low malignant potential. Proper identification is important to secure adequate treatment and follow-up.

Original languageEnglish (US)
Pages (from-to)796-804
Number of pages9
JournalAmerican Journal of Clinical Pathology
Volume144
Issue number5
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

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Follicular Adenocarcinoma
Thyroglobulin
Fluorescence In Situ Hybridization
Kidney
Monosomy
Neoplasms
Trisomy
Vimentin
Renal Cell Carcinoma
Adenoma
Thyroid Gland
Chromosomes
Observation
Recurrence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Thyroid-like follicular carcinoma of the kidney : One case report and review of the literature. / Dawane, Rahul; Grindstaff, Alan; Parwani, Anil V.; Brock, Timothy; White, Wesley; Nodit, Laurentia.

In: American Journal of Clinical Pathology, Vol. 144, No. 5, 01.01.2015, p. 796-804.

Research output: Contribution to journalArticle

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