Thyrotropin-releasing hormone levels decrease in hypothalamus of aging rats

A. Eugene Pekary, Harold E. Carlson, Tadataka Yamada, Burt Sharp, Paul G. Walfish, Jerome M. Hershman

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Because hypothalamic and extrahypothalamic levels of thyrotropin-releasing hormone immunoreactivity (TRH-IR) undergo profound changes during the prenatal and early postnatal period in rats, similar effects with advanced aging were anticipated. For this reason we measured hypothalamic and reproductive tissue levels of TRH-IR, hypothalamic levels of somatostatin (SRIF), and β-endorophin (EP), serum levels of prolactin (Prl), growth hormone (GH), thyrotropin (TSH), and thyroxine (T4) in young, sexually mature and 24-28 month-old male Long-Evans and Sprague-Dawley rats. Hypothalamic and prostatic levels of TRH-IR were consistently reduced as were the levels of T4 in old rats compared to young controls. Aging did not change the ratio of TRH to the major TRH-like peptide in prostates, as determined by high pressure liquid chromatography (HPLC) or the levels of hypothalamic SRIF and EP. All of the hypothalamic TRH-IR in both old and young male rats consisted of TRH by HPLC. Falling hypothalamic TRH levels and TRH secretory capacity may play a role in the blunted TSH response to cold stress in old rats.

Original languageEnglish (US)
Pages (from-to)221-226
Number of pages6
JournalNeurobiology of Aging
Volume5
Issue number3
DOIs
StatePublished - Jan 1 1984

Fingerprint

Thyrotropin-Releasing Hormone
Hypothalamus
Cold-Shock Response
High Pressure Liquid Chromatography
Pituitary Hormone-Releasing Hormones
Thyrotropin
Somatostatin
Thyroxine
Prolactin
Growth Hormone
Sprague Dawley Rats
Prostate
Peptides
Serum

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

Pekary, A. E., Carlson, H. E., Yamada, T., Sharp, B., Walfish, P. G., & Hershman, J. M. (1984). Thyrotropin-releasing hormone levels decrease in hypothalamus of aging rats. Neurobiology of Aging, 5(3), 221-226. https://doi.org/10.1016/0197-4580(84)90066-6

Thyrotropin-releasing hormone levels decrease in hypothalamus of aging rats. / Pekary, A. Eugene; Carlson, Harold E.; Yamada, Tadataka; Sharp, Burt; Walfish, Paul G.; Hershman, Jerome M.

In: Neurobiology of Aging, Vol. 5, No. 3, 01.01.1984, p. 221-226.

Research output: Contribution to journalArticle

Pekary, AE, Carlson, HE, Yamada, T, Sharp, B, Walfish, PG & Hershman, JM 1984, 'Thyrotropin-releasing hormone levels decrease in hypothalamus of aging rats', Neurobiology of Aging, vol. 5, no. 3, pp. 221-226. https://doi.org/10.1016/0197-4580(84)90066-6
Pekary, A. Eugene ; Carlson, Harold E. ; Yamada, Tadataka ; Sharp, Burt ; Walfish, Paul G. ; Hershman, Jerome M. / Thyrotropin-releasing hormone levels decrease in hypothalamus of aging rats. In: Neurobiology of Aging. 1984 ; Vol. 5, No. 3. pp. 221-226.
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