Tight control of trehalose content is required for efficient heat-induced cell elongation in Candida albicans

Joke Serneels, Helene Tournu, Patrick Van Dijck

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Heat-induced morphogenetic switch is Hsp90- and PKA-dependent. Results: The G protein-coupled receptor Gpr1, upstream of PKA, regulates trehalose levels in glucose-grown cells. Conclusion: The link between the PKA pathway and Hsp90-mediated regulation of heat-induced morphogenesis is trehalose. Significance: Tight control of trehalose levels is required for morphogenesis in Candida albicans.

Original languageEnglish (US)
Pages (from-to)36873-36882
Number of pages10
JournalJournal of Biological Chemistry
Volume287
Issue number44
DOIs
StatePublished - Oct 26 2012

Fingerprint

Trehalose
Candida
Candida albicans
Elongation
Hot Temperature
Morphogenesis
G-Protein-Coupled Receptors
Switches
Glucose

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Tight control of trehalose content is required for efficient heat-induced cell elongation in Candida albicans. / Serneels, Joke; Tournu, Helene; Van Dijck, Patrick.

In: Journal of Biological Chemistry, Vol. 287, No. 44, 26.10.2012, p. 36873-36882.

Research output: Contribution to journalArticle

@article{c752d6b842914f32809b14e36898c7fb,
title = "Tight control of trehalose content is required for efficient heat-induced cell elongation in Candida albicans",
abstract = "Background: Heat-induced morphogenetic switch is Hsp90- and PKA-dependent. Results: The G protein-coupled receptor Gpr1, upstream of PKA, regulates trehalose levels in glucose-grown cells. Conclusion: The link between the PKA pathway and Hsp90-mediated regulation of heat-induced morphogenesis is trehalose. Significance: Tight control of trehalose levels is required for morphogenesis in Candida albicans.",
author = "Joke Serneels and Helene Tournu and {Van Dijck}, Patrick",
year = "2012",
month = "10",
day = "26",
doi = "10.1074/jbc.M112.402651",
language = "English (US)",
volume = "287",
pages = "36873--36882",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "44",

}

TY - JOUR

T1 - Tight control of trehalose content is required for efficient heat-induced cell elongation in Candida albicans

AU - Serneels, Joke

AU - Tournu, Helene

AU - Van Dijck, Patrick

PY - 2012/10/26

Y1 - 2012/10/26

N2 - Background: Heat-induced morphogenetic switch is Hsp90- and PKA-dependent. Results: The G protein-coupled receptor Gpr1, upstream of PKA, regulates trehalose levels in glucose-grown cells. Conclusion: The link between the PKA pathway and Hsp90-mediated regulation of heat-induced morphogenesis is trehalose. Significance: Tight control of trehalose levels is required for morphogenesis in Candida albicans.

AB - Background: Heat-induced morphogenetic switch is Hsp90- and PKA-dependent. Results: The G protein-coupled receptor Gpr1, upstream of PKA, regulates trehalose levels in glucose-grown cells. Conclusion: The link between the PKA pathway and Hsp90-mediated regulation of heat-induced morphogenesis is trehalose. Significance: Tight control of trehalose levels is required for morphogenesis in Candida albicans.

UR - http://www.scopus.com/inward/record.url?scp=84868217592&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868217592&partnerID=8YFLogxK

U2 - 10.1074/jbc.M112.402651

DO - 10.1074/jbc.M112.402651

M3 - Article

VL - 287

SP - 36873

EP - 36882

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 44

ER -