Timing and mechanism of ischemic stroke due to extracranial blunt traumatic cerebrovascular injury ; Clinical article

Christoph J. Griessenauer, J. Brett Fleming, Boyd F. Richards, Luis P. Cava, Joel K. Curé, Duraid S. Younan, Limin Zhao, Andrei Alexandrov, Kristian Barlinn, Tracy Taylor, Mark R. Harrigan

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Object. Extracranial cerebrovascular injury is believed to be an important cause of neurological injury in patients who have suffered blunt trauma. The authors sought to determine the timing and mechanisms of ischemic stroke in patients who suffered traumatic cerebrovascular injury (TCVI). Methods. This is a prospective study of all patients with TCVI who were admitted to a Level I trauma center during a 28-month period. All patients who suffered blunt trauma and had risk factors for TCVI underwent screening CT angiography (CTA) of the head and neck on admission. All patients with either an ischemic stroke or CTA suggesting TCVI underwent confirmatory digital subtraction angiography (DSA). Patients with DSA-confirmed TCVI were treated with 325 mg aspirin daily; all patients were observed during their hospitalization for the occurrence of new ischemic stroke. In addition, a subset of patients with TCVI underwent transcranial Doppler ultrasonography monitoring for microembolic signals. Results. A total of 112 patients had CTA findings suggestive of TCVI; 68 cases were confirmed by DSA. Overall, 7 patients had an ischemic stroke in the territory of the affected artery prior to or during admission. Four of the patients had their event prior to diagnosis with CTA and 2 occurred prior to DSA. In 1 patient the ischemic stroke was found to be due to an extracranial atherosclerotic carotid plaque, and this patient was excluded from further analysis. All patients with ischemic stroke had brain CT findings consistent with an embolic mechanism. Two (8.7%) of 23 monitored patients with TCVI had microembolic signals on transcranial Doppler ultrasonography. Conclusions. Most ischemic strokes due to TCVI are embolic in nature and occur prior to screening CTA and initiation of treatment with aspirin.

Original languageEnglish (US)
Pages (from-to)397-404
Number of pages8
JournalJournal of neurosurgery
Volume118
Issue number2
DOIs
StatePublished - Feb 1 2013

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Stroke
Wounds and Injuries
Digital Subtraction Angiography
Doppler Transcranial Ultrasonography
Aspirin
Trauma Centers
Atherosclerotic Plaques
Hospitalization
Neck
Arteries
Head
Computed Tomography Angiography
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

Griessenauer, C. J., Brett Fleming, J., Richards, B. F., Cava, L. P., Curé, J. K., Younan, D. S., ... Harrigan, M. R. (2013). Timing and mechanism of ischemic stroke due to extracranial blunt traumatic cerebrovascular injury ; Clinical article. Journal of neurosurgery, 118(2), 397-404. https://doi.org/10.3171/2012.11.JNS121038

Timing and mechanism of ischemic stroke due to extracranial blunt traumatic cerebrovascular injury ; Clinical article. / Griessenauer, Christoph J.; Brett Fleming, J.; Richards, Boyd F.; Cava, Luis P.; Curé, Joel K.; Younan, Duraid S.; Zhao, Limin; Alexandrov, Andrei; Barlinn, Kristian; Taylor, Tracy; Harrigan, Mark R.

In: Journal of neurosurgery, Vol. 118, No. 2, 01.02.2013, p. 397-404.

Research output: Contribution to journalArticle

Griessenauer, CJ, Brett Fleming, J, Richards, BF, Cava, LP, Curé, JK, Younan, DS, Zhao, L, Alexandrov, A, Barlinn, K, Taylor, T & Harrigan, MR 2013, 'Timing and mechanism of ischemic stroke due to extracranial blunt traumatic cerebrovascular injury ; Clinical article', Journal of neurosurgery, vol. 118, no. 2, pp. 397-404. https://doi.org/10.3171/2012.11.JNS121038
Griessenauer, Christoph J. ; Brett Fleming, J. ; Richards, Boyd F. ; Cava, Luis P. ; Curé, Joel K. ; Younan, Duraid S. ; Zhao, Limin ; Alexandrov, Andrei ; Barlinn, Kristian ; Taylor, Tracy ; Harrigan, Mark R. / Timing and mechanism of ischemic stroke due to extracranial blunt traumatic cerebrovascular injury ; Clinical article. In: Journal of neurosurgery. 2013 ; Vol. 118, No. 2. pp. 397-404.
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AU - Cava, Luis P.

AU - Curé, Joel K.

AU - Younan, Duraid S.

AU - Zhao, Limin

AU - Alexandrov, Andrei

AU - Barlinn, Kristian

AU - Taylor, Tracy

AU - Harrigan, Mark R.

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N2 - Object. Extracranial cerebrovascular injury is believed to be an important cause of neurological injury in patients who have suffered blunt trauma. The authors sought to determine the timing and mechanisms of ischemic stroke in patients who suffered traumatic cerebrovascular injury (TCVI). Methods. This is a prospective study of all patients with TCVI who were admitted to a Level I trauma center during a 28-month period. All patients who suffered blunt trauma and had risk factors for TCVI underwent screening CT angiography (CTA) of the head and neck on admission. All patients with either an ischemic stroke or CTA suggesting TCVI underwent confirmatory digital subtraction angiography (DSA). Patients with DSA-confirmed TCVI were treated with 325 mg aspirin daily; all patients were observed during their hospitalization for the occurrence of new ischemic stroke. In addition, a subset of patients with TCVI underwent transcranial Doppler ultrasonography monitoring for microembolic signals. Results. A total of 112 patients had CTA findings suggestive of TCVI; 68 cases were confirmed by DSA. Overall, 7 patients had an ischemic stroke in the territory of the affected artery prior to or during admission. Four of the patients had their event prior to diagnosis with CTA and 2 occurred prior to DSA. In 1 patient the ischemic stroke was found to be due to an extracranial atherosclerotic carotid plaque, and this patient was excluded from further analysis. All patients with ischemic stroke had brain CT findings consistent with an embolic mechanism. Two (8.7%) of 23 monitored patients with TCVI had microembolic signals on transcranial Doppler ultrasonography. Conclusions. Most ischemic strokes due to TCVI are embolic in nature and occur prior to screening CTA and initiation of treatment with aspirin.

AB - Object. Extracranial cerebrovascular injury is believed to be an important cause of neurological injury in patients who have suffered blunt trauma. The authors sought to determine the timing and mechanisms of ischemic stroke in patients who suffered traumatic cerebrovascular injury (TCVI). Methods. This is a prospective study of all patients with TCVI who were admitted to a Level I trauma center during a 28-month period. All patients who suffered blunt trauma and had risk factors for TCVI underwent screening CT angiography (CTA) of the head and neck on admission. All patients with either an ischemic stroke or CTA suggesting TCVI underwent confirmatory digital subtraction angiography (DSA). Patients with DSA-confirmed TCVI were treated with 325 mg aspirin daily; all patients were observed during their hospitalization for the occurrence of new ischemic stroke. In addition, a subset of patients with TCVI underwent transcranial Doppler ultrasonography monitoring for microembolic signals. Results. A total of 112 patients had CTA findings suggestive of TCVI; 68 cases were confirmed by DSA. Overall, 7 patients had an ischemic stroke in the territory of the affected artery prior to or during admission. Four of the patients had their event prior to diagnosis with CTA and 2 occurred prior to DSA. In 1 patient the ischemic stroke was found to be due to an extracranial atherosclerotic carotid plaque, and this patient was excluded from further analysis. All patients with ischemic stroke had brain CT findings consistent with an embolic mechanism. Two (8.7%) of 23 monitored patients with TCVI had microembolic signals on transcranial Doppler ultrasonography. Conclusions. Most ischemic strokes due to TCVI are embolic in nature and occur prior to screening CTA and initiation of treatment with aspirin.

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